Publication Name	World Journal of Diabetes
Manuscript ID	91602
Country	India

Received	2023-12-31 13:28
Peer-Review Started	2023-12-31 13:28
To Make the First Decision
Return for Revision	2024-01-16 05:34
Revised	2024-01-22 17:21
Second Decision	2024-02-20 00:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-02-27 06:17
Articles in Press	2024-02-27 06:17
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-03-02 22:42
Typeset the Manuscript	2024-03-26 07:30
Publish the Manuscript Online	2024-04-12 01:04

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Infectious Diseases
Manuscript Type	Review
Article Title	Role of renin-angiotensin system/angiotensin converting enzyme-2 mechanism and enhanced COVID-19 susceptibility in type 2 diabetes mellitus
Manuscript Source	Invited Manuscript
All Author List	Ashwin Kumar Shukla, Komal Awasthi, Kauser Usman and Monisha Banerjee
ORCID	Author(s) ORCID Number Ashwin Kumar Shukla http://orcid.org/0000-0003-1554-090X Komal Awasthi http://orcid.org/0009-0007-3069-4356 Monisha Banerjee http://orcid.org/0000-0002-5371-8791
Funding Agency and Grant Number
Corresponding Author	Monisha Banerjee, PhD, Professor, Molecular and Human Genetics Laboratory, Department of Zoology, University of Lucknow, University Road, Lucknow 226007, Uttar Pradesh, India. monishabanerjee30@gmail.com
Key Words	Angiotensin-converting enzyme 2; Angiotensin-converting enzyme inhibitors; Angiotensin-II receptor blockers; Complex diseases; COVID-19; Type 2 diabetes
Core Tip	This manuscript explores the complex connection between type 2 diabetes mellitus (T2DM) and coronavirus disease 2019 (COVID-19), emphasizing on heightened susceptibility of diabetic individuals. It reveals the crucial involvement of the renin-angiotensin system (RAS) and angiotensin converting enzyme (ACE)/ACE2 enzymes, clarifying how decreased ACE2 expression in diabetes amplifies RAS activity, contributing to inflammation and fibrosis. While ACE inhibitors exhibit therapeutic potential, concerns arise regarding their potential to facilitate COVID-19 entry. The review suggests innovative approaches, including recombinant human angiotensin converting enzyme 2 therapy and the detection of epigenetic signatures, presenting promising avenues for addressing COVID-19 and its complications in T2D.
Publish Date	2024-04-12 01:04
Citation	Shukla AK, Awasthi K, Usman K, Banerjee M. Role of renin-angiotensin system/angiotensin converting enzyme-2 mechanism and enhanced COVID-19 susceptibility in type 2 diabetes mellitus. World J Diabetes 2024; 15(4): 606-622
URL	https://www.wjgnet.com/1948-9358/full/v15/i4/606.htm
DOI	https://dx.doi.org/10.4239/wjd.v15.i4.606

Full Article (PDF)	WJD-15-606-with-cover.pdf
Manuscript File	91602_Review-FilipodiaCL.docx
Answering Reviewers	91602-Answering reviewers.pdf
Audio Core Tip	91602-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	91602-Conflict-of-interest statement.pdf
Copyright License Agreement	91602-Copyright license agreement.pdf
Peer-review Report	91602-Peer-review(s).pdf
Scientific Misconduct Check	91602-Bing-Chen YL-2.png
Scientific Editor Work List	91602-Scientific editor work list.pdf