Publication Name	World Journal of Clinical Cases
Manuscript ID	91615
Country	Croatia

Received	2023-12-31 17:51
Peer-Review Started	2023-12-31 17:51
To Make the First Decision
Return for Revision	2024-01-10 23:32
Revised	2024-01-25 22:16
Second Decision	2024-03-14 04:25
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-03-14 07:07
Articles in Press	2024-03-14 07:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-25 10:12
Publish the Manuscript Online	2024-04-02 09:09

ISSN	2307-8960 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Discontinuation of therapy in inflammatory bowel disease: Current views
Manuscript Source	Invited Manuscript
All Author List	Antonio Meštrović, Marko Kumric and Josko Bozic
ORCID	Author(s) ORCID Number Antonio Meštrović http://orcid.org/0000-0002-0156-2748 Marko Kumric http://orcid.org/0000-0002-9696-3359 Josko Bozic http://orcid.org/0000-0003-1634-0635
Funding Agency and Grant Number
Corresponding Author	Josko Bozic, MD, PhD, Associate Professor, Department of Pathophysiology, University of Split School of Medicine, Soltanska 2, Split 21000, Croatia. josko.bozic@mefst.hr
Key Words	Inflammatory bowel disease; Therapy discontinuation; Therapy de-escalation; Ulcerative colitis; Crohn’s disease
Core Tip	Tailoring treatment for inflammatory bowel disease (IBD) hinges on timely drug initiation aligned with treatment objectives. While therapy approaches evolve, achieving and sustaining remission prompts discussions on de-escalating or halting treatment, weighed against long-term therapy risks. With each IBD drug category, relapse risks persist post-discontinuation, impacting over 50% of patients. Withdrawal following combination therapies shows prolonged relapse-free periods, yet randomized trials on medication cessation are limited. Identifying relapse predictors and suitable candidates is pivotal. Re-treatment success underpins therapy withdrawal decisions. Individualized assessments, considering disease severity, duration, side effects, relapse risk, and patient preferences all guide prudent discontinuation choices.
Publish Date	2024-04-02 09:09
Citation	Meštrović A, Kumric M, Bozic J. Discontinuation of therapy in inflammatory bowel disease: Current views. World J Clin Cases 2024; 12(10): 1718-1727
URL	https://www.wjgnet.com/2307-8960/full/v12/i10/1718.htm
DOI	https://dx.doi.org/10.12998/wjcc.v12.i10.1718

Full Article (PDF)	WJCC-12-1718-with-cover.pdf
Manuscript File	91615_Auto_Edited-YJP.docx
Answering Reviewers	91615-Answering reviewers.pdf
Audio Core Tip	91615-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	91615-Conflict-of-interest statement.pdf
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Non-Native Speakers of English Editing Certificate	91615-Language certificate.pdf
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