Publication Name	World Journal of Cardiology
Manuscript ID	9178
Country	United States

Received	2014-01-24 17:14
Peer-Review Started	2014-01-24 22:44
First Decision by Editorial Office Director
Return for Revision	2014-03-11 21:07
Revised	2014-06-28 00:00
Publication Fee Transferred
Second Decision by Editor	2014-07-15 14:53
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-07-15 15:06
Articles in Press	2014-07-15 17:06
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-25 16:25
Publish the Manuscript Online	2014-09-28 08:35

ISSN	1949-8462 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Medicine, General & Internal
Manuscript Type	Topic Highlights
Article Title	African Americans, hypertension and the renin angiotensin system
Manuscript Source	Invited Manuscript
All Author List	Sandra F Williams, Susanne B Nicholas, Nosratola D Vaziri and Keith C Norris
Funding Agency and Grant Number	Funding Agency Grant Number National Institutes of Health UL1TR000124 National Institutes of Health P30AG021684 National Institutes of Health P20-MD000182 National Institutes of Health DK065455
Corresponding Author	Keith C Norris, MD, FASN, Professor of Medicine, Division of General Internal Medicine and Health Services Research, 911 Broxton Ave, Room 103, Los Angeles, CA 90024, United States. kcnorris@mednet.ucla.edu
Key Words	African American; Blood pressure; Ethnicity; Hypertension; Renin; Angiotensin
Core Tip	African Americans have exceptionally high rates of hypertension and hypertension related complications. Due to a greater likelihood of having a low plasma renin levels, inhibitors of the renin angiotensin system (RAS) are often not recommended as initial antihypertensive therapy. However, animal models suggest hypertension characterized by low circulating renin levels have a paradoxical increase in tissue RAS activity. Thus treatment with RAS inhibitors may be critical to preventing end organ damage. We describe the rationale of RAS blockade as part of a comprehensive approach to attenuate the high rates of premature morbidity and mortality associated with hypertension among African Americans.
Publish Date	2014-09-28 08:35
Citation	Williams SF, Nicholas SB, Vaziri ND, Norris KC. African Americans, hypertension and the renin angiotensin system. World J Cardiol 2014; 6(9): 878-889
URL	http://www.wjgnet.com/1949-8462/full/v6/i9/878.htm
DOI	http://dx.doi.org/10.4330/wjc.v6.i9.878

Full Article (PDF)	WJC-6-878.pdf
Full Article (Word)	WJC-6-878.doc
Manuscript File	9178-Review.docx
Answering Reviewers	9178-Answering reviewers.pdf
Copyright License Agreement	9178-Copyright assignment.pdf
Peer-review Report	9178-Peer review(s).pdf
Scientific Misconduct Check	9178-CrossCheck.jpg
Scientific Editor Work List	9178-Scientific editor work list.pdf