Publication Name	World Journal of Anesthesiology
Manuscript ID	9280
Country	Taiwan

Received	2014-01-29 22:28
Peer-Review Started	2014-01-30 17:45
To Make the First Decision	2014-02-13 16:16
Return for Revision	2014-02-20 23:55
Revised	2014-04-10 23:38
Second Decision	2014-06-11 13:26
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-11 13:40
Articles in Press	2014-06-11 13:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-18 21:36
Publish the Manuscript Online	2014-08-20 21:05

ISSN	2218-6182 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Anesthesiology
Manuscript Type	Review
Article Title	Lumbar radiculopathy and its neurobiological basis
Manuscript Source	Invited Manuscript
All Author List	Jiann-Her Lin, Yung-Hsiao Chiang and Chih-Cheng Chen
Funding Agency and Grant Number	Funding Agency Grant Number Taipei Medical University TMU101-AE3-Y24 (to JH Lin) Taipei Medical University 2325-B-001-015 (to Chen CC) Ministry of Science and Technology, Taiwan NSC 102-2325-B-001-042 (to Chen CC) Ministry of Science and Technology, Taiwan NSC102-2321-B-001-056 (to Chen CC) Ministry of Science and Technology, Taiwan NSC 102-2320-B-001-021-MY3 (to Chen CC)
Corresponding Author	Chih-Cheng Chen, PhD, Institue of Biomedical Sciences, Academai Sinica, 128 Academia Road, Section 2, Taipei 11574, Taiwan. chih@ibms.sinica.edu.tw
Key Words	Low back pain; Acid-sensing ion channel; Dorsal root; Dorsal root ganglia; Disc herniation; Lumbar spine
Core Tip	Lumbar radiculopathy is the most common form of neuropathic pain. However, the diagnosis of lumbar radiculopathy is still not satisfactory because of the largely unknown neurobiological basis of neuropathic pain and paresthesia. Accumulating evidence has shown that lumbar radiculopathy is a multi-factor disease and may involve almost all types of pain, including ischemic, inflammatory, mechanical, and neuropathic pain. Ion channels such as Acid-sensing ion channel 3, Piezo2 and transient receptor potential vanilloid receptor 1 responding to tissue acidosis, mechanical force, and inflammatory mediators may be the pathways transducing the pain.
Publish Date	2014-08-20 21:05
Citation	Lin JH, Chiang YH, Chen CC. Lumbar radiculopathy and its neurobiological basis. World J Anesthesiol 2014; 3(2): 162-173
URL	http://www.wjgnet.com/2218-6182/full/v3/i2/162.htm
DOI	http://dx.doi.org/10.5313/wja.v3.i2.162

Full Article (PDF)	WJA-3-162.pdf
Full Article (Word)	WJA-3-162.doc
Manuscript File	9280-Review.docx
Answering Reviewers	9280-Answering reviewers.pdf
Copyright License Agreement	9280-Copyright assignment.pdf
Peer-review Report	9280-Peer review(s).pdf
Scientific Misconduct Check	9280-CrossCheck.jpg
Scientific Editor Work List	9280-Scientific editor work list.pdf