Publication Name	World Journal of Gastroenterology
Manuscript ID	9287
Country	Canada

Received	2014-01-30 08:31
Peer-Review Started	2014-02-08 14:16
To Make the First Decision	2014-02-27 13:54
Return for Revision	2014-03-11 13:48
Revised	2014-03-17 07:49
Second Decision	2014-04-23 09:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-04-23 10:25
Articles in Press	2014-05-23 10:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-24 17:40
Publish the Manuscript Online	2014-09-07 13:31

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Impact of medical therapy on patients with Crohn’s disease requiring surgical resection
Manuscript Source	Unsolicited Manuscript
All Author List	YT Nancy Fu, Thomas Hong, Andrew Round and Brian Bressler
Funding Agency and Grant Number
Corresponding Author	YT Nancy Fu, MD, FRCPC, Division of Gastroenterology, Department of Medicine, University of British Columbia, St. Paul’s Hospital, 770-1190 Hornby Street, Vancouver, BC V6Z 1Y6, Canada. nfu@interchange.ubc.ca
Key Words	Crohn’s disease; Surgery; Medication; Phenotype; Biologics; Anti-tumor necrosis factor; Immunomodulators; Inflammatory bowel disease
Core Tip	Comparing two cohorts separated by a decade of Crohn’s disease patients who required surgical resections, this study showed significant changes in patient phenotypes and medication usage. Those that required surgery shifted from more inflammatory to stricturing and penetrating phenotypes, and had more immunomodulators but less 5-aminosalysilic acid exposures. Patients treated with biologics had significantly longer time from Crohn’s disease diagnosis to surgery. However, they were at increased risk for surgery, suggesting that biologics were often used too late in the patients’ treatment courses.
Publish Date	2014-09-07 13:31
Citation	Fu YTN, Hong T, Round A, Bressler B. Impact of medical therapy on patients with Crohn’s disease requiring surgical resection. World J Gastroenterol 2014; 20(33): 11808-11814
URL	http://www.wjgnet.com/1007-9327/full/v20/i33/11808.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i33.11808

Full Article (PDF)	WJG-20-11808.pdf
Full Article (Word)	WJG-20-11808.doc
Manuscript File	9287-Review.doc
Answering Reviewers	9287-Answering reviewers.pdf
Biostatistics Review Certificate	Biostatistician_Review_Report_20140129060149.docx
Copyright License Agreement	9287-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20140129060038.pdf
Peer-review Report	9287-Peer reviews.pdf
Scientific Editor Work List	9287-Scientific editor work list.doc