Publication Name	World Journal of Clinical Oncology
Manuscript ID	9467
Country	Saudi Arabia

Received	2014-02-13 14:17
Peer-Review Started	2014-02-13 20:01
To Make the First Decision	2014-04-15 15:21
Return for Revision	2014-04-16 17:12
Revised	2014-04-16 19:44
Second Decision	2014-06-11 12:24
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-11 12:32
Articles in Press	2014-06-11 14:58
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-06-15 02:11
Typeset the Manuscript	2014-07-25 11:48
Publish the Manuscript Online	2014-12-11 14:23

ISSN	2218-4333 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Autobiography
Article Title	Clinicopathological features and treatment outcomes of brain stem gliomas in Saudi population
Manuscript Source	Unsolicited Manuscript
All Author List	Yasser Bayoumi, Abdulrahman J Sabbagh, Reham Mohamed, Usama M ElShokhaiby, Ahmed Marzouk Maklad, Mutahir A Tunio and Ali Abdullah O Balbaid
Funding Agency and Grant Number
Corresponding Author	Mutahir A Tunio, FCPS (Radiation Oncology), Assistant Consultant, Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City, Khurais Road, Riyadh-59046, Saudi Arabia. mkhairuddin@kfmc.med.sa
Key Words	Brain stem glioma; Children; Adults; Saudi Arabia; Treatment outcomes
Core Tip	Brain stem gliomas (BSG) are a heterogeneous group of tumors with a poor prognosis. We analyzed 49 BSG patients from July 2001 to December 2012 with a median age of 12.6 years (range: 8-64 mo). Twenty-two patients (44.9%) had diffuse intrinsic pontine gliomas (DIPG) and 15 (30.6%) presented with focal/tectal BSG. Histopathology was available in 30 patients (61.2%). Median survival time for the whole cohort was 1.5 years. One and two year OS rates were 51.1% and 41.9% respectively. Two year OS rates for focal/tectal, dorsally exophytic, cervicomedullary and DIPG tumors were 60%, 33.3%, 33.3% and 13.6% respectively (P < 0.0001). We concluded that BSG, especially the DIPG subgroup, had a dismal prognosis, needing more aggressive neurosurgical, radiation and chemotherapy techniques, while focal and tectal tumors were found to have a better prognosis.
Publish Date	2014-12-11 14:23
Citation	Bayoumi Y, Sabbagh AJ, Mohamed R, ElShokhaiby UM, Maklad AM, Tunio MA, Balbaid AAO. Clinicopathological features and treatment outcomes of brain stem gliomas in Saudi population. World J Clin Oncol 2014; 5(5): 1060-1067
URL	http://www.wjgnet.com/2218-4333/full/v5/i5/1060.htm
DOI	http://dx.doi.org/10.5306/wjco.v5.i5.1060

Full Article (PDF)	WJCO-5-1060.pdf
Full Article (Word)	WJCO-5-1060.doc
Manuscript File	9467-Review.docx
Answering Reviewers	9467-Answering reviewers.pdf
Copyright License Agreement	9467-Copyright assignment.pdf
Peer-review Report	9467-Peer review(s).pdf
Scientific Misconduct Check	9467-CrossCheck.jpg
Scientific Editor Work List	9467-Scientific editor work list.pdf