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9/16/2014 10:38:00 AM | Browse: 1006 | Download: 1119
Publication Name World Journal of Clinical Cases
Manuscript ID 9564
Country/Territory Canada
Received
2014-02-18 09:19
Peer-Review Started
2014-02-18 13:46
To Make the First Decision
2014-04-04 16:11
Return for Revision
2014-04-09 10:42
Revised
2014-04-29 10:25
Second Decision
2014-06-16 14:00
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-06-16 14:13
Articles in Press
2014-06-16 14:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-08-01 08:29
Publish the Manuscript Online
2014-09-03 20:56
ISSN 2307-8960 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Case Report
Article Title Prucalopride-associated acute tubular necrosis
Manuscript Source Unsolicited Manuscript
All Author List Vithika Sivabalasundaram, Flavio Habal and David Cherney
Funding Agency and Grant Number
Funding Agency Grant Number
Kidney Foundation of Canada Scholarship
Canadian Diabetes Association-KRESCENT Program Joint New Investigator Award
Canadian Institutes of Health Research
Heart and Stroke Foundation of Canada to Cherney D
Corresponding Author Flavio Habal, MD, Department of Medicine, Division of Gastroenterology, Toronto General Hospital, University of Toronto, 200 Elizabeth St, 9N-977, Toronto, M5G 2C4, Canada. flavio.habal@uhn.ca
Key Words Prucalopride; Acute kidney tubular necrosis; Renal insufficiency; Constipation; Adverse drug event
Core Tip Prucalopride is a novel agent used in the treatment of chronic constipation. We report the first case of acute renal failure secondary to prucalopride four months after treatment initiation. A core renal biopsy after prednisone therapy revealed interstitial fibrosis and tubular atrophy. These findings suggested acute tubular necrosis secondary to acute interstitial nephritis. There are no previous reports of prucalopride associated with acute renal failure from the literature, including previous Phase Ⅱ and Ⅲ trials. This case reports highlights the need for monitoring renal function in all patients treated with prucalopride .
Publish Date 2014-09-03 20:56
Citation Sivabalasundaram V, Habal F, Cherney D. Prucalopride-associated acute tubular necrosis. World J Clin Cases 2014; 2(8): 380-384
URL http://www.wjgnet.com/2307-8960/full/v2/i8/380.htm
DOI http://dx.doi.org/10.12998/wjcc.v2.i8.380
Full Article (PDF) WJCC-2-380.pdf
Full Article (Word) WJCC-2-380.doc
Manuscript File 9564-Review.docx
Answering Reviewers 9564-Answering reviewers.pdf
Copyright License Agreement 9564-Copyright assignment.pdf
Peer-review Report 9564-Peer review(s).pdf
Scientific Misconduct Check 9564-CrossCheck.jpg
Scientific Editor Work List 9564-Scientific editor work list.pdf