Publication Name	World Journal of Clinical Cases
Manuscript ID	9564
Country	Canada

Received	2014-02-18 09:19
Peer-Review Started	2014-02-18 13:46
To Make the First Decision	2014-04-04 16:11
Return for Revision	2014-04-09 10:42
Revised	2014-04-29 10:25
Second Decision	2014-06-16 14:00
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-16 14:13
Articles in Press	2014-06-16 14:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-01 08:29
Publish the Manuscript Online	2014-09-03 20:56

ISSN	2307-8960 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Prucalopride-associated acute tubular necrosis
Manuscript Source	Unsolicited Manuscript
All Author List	Vithika Sivabalasundaram, Flavio Habal and David Cherney
Funding Agency and Grant Number	Funding Agency Grant Number Kidney Foundation of Canada Scholarship Canadian Diabetes Association-KRESCENT Program Joint New Investigator Award Canadian Institutes of Health Research Heart and Stroke Foundation of Canada to Cherney D
Corresponding Author	Flavio Habal, MD, Department of Medicine, Division of Gastroenterology, Toronto General Hospital, University of Toronto, 200 Elizabeth St, 9N-977, Toronto, M5G 2C4, Canada. flavio.habal@uhn.ca
Key Words	Prucalopride; Acute kidney tubular necrosis; Renal insufficiency; Constipation; Adverse drug event
Core Tip	Prucalopride is a novel agent used in the treatment of chronic constipation. We report the first case of acute renal failure secondary to prucalopride four months after treatment initiation. A core renal biopsy after prednisone therapy revealed interstitial fibrosis and tubular atrophy. These findings suggested acute tubular necrosis secondary to acute interstitial nephritis. There are no previous reports of prucalopride associated with acute renal failure from the literature, including previous Phase Ⅱ and Ⅲ trials. This case reports highlights the need for monitoring renal function in all patients treated with prucalopride .
Publish Date	2014-09-03 20:56
Citation	Sivabalasundaram V, Habal F, Cherney D. Prucalopride-associated acute tubular necrosis. World J Clin Cases 2014; 2(8): 380-384
URL	http://www.wjgnet.com/2307-8960/full/v2/i8/380.htm
DOI	http://dx.doi.org/10.12998/wjcc.v2.i8.380

Full Article (PDF)	WJCC-2-380.pdf
Full Article (Word)	WJCC-2-380.doc
Manuscript File	9564-Review.docx
Answering Reviewers	9564-Answering reviewers.pdf
Copyright License Agreement	9564-Copyright assignment.pdf
Peer-review Report	9564-Peer review(s).pdf
Scientific Misconduct Check	9564-CrossCheck.jpg
Scientific Editor Work List	9564-Scientific editor work list.pdf