Publication Name	World Journal of Gastroenterology
Manuscript ID	9587
Country	Italy

Received	2014-02-19 09:52
Peer-Review Started	2014-02-19 12:33
To Make the First Decision	2014-03-27 21:15
Return for Revision	2014-03-31 10:06
Revised	2014-04-10 00:00
Second Decision	2014-05-26 21:31
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-26 21:49
Articles in Press	2014-05-26 22:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-07 18:30
Publish the Manuscript Online	2014-08-20 18:38

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Evidence-Based Medicine
Article Title	Electrochemiluminescence immunoassay method underestimates cortisol suppression in ulcerative colitis patients treated with oral prednisone
Manuscript Source	Unsolicited Manuscript
All Author List	Francesco Manguso, Raffaele Bennato, Giovanni Lombardi, Assunta Viola, Elisabetta Riccio and Livio Cipolletta
Funding Agency and Grant Number
Corresponding Author	Francesco Manguso, MD, PhD, Division of Gastroenterology, Cardarelli Hospital, Via A. Cardarelli 9, Naples 80131, Italy. manguso@alice.it
Key Words	Cortisol; Immunoassay; Liquid chromatography; Prednisone; Tandem mass spectrometry; Ulcerative colitis
Core Tip	The determination of morning cortisol levels is used in clinical practice and as specific safety endpoint in various clinical trials. This study was designed to compare the efficacy of electrochemiluminescent assays (ECLIA) method and liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for measurement of cortisolemia in active ulcerative colitis (UC) patients treated with oral prednisone (PD). Blood cortisol levels detected with ECLIA method are higher than the ones measured by LC-MS/MS, indicating a possible overestimation of them in UC patients treated with PD. Therefore, the cortisol suppression in patients under treatment with oral PD should not be measured using ECLIA method.
Publish Date	2014-08-20 18:38
Citation	Manguso F, Bennato R, Lombardi G, Viola A, Riccio E, Cipolletta L. Electrochemiluminescence immunoassay method underestimates cortisol suppression in ulcerative colitis patients treated with oral prednisone. World J Gastroenterol 2014; 20(31): 10895-10899
URL	http://www.wjgnet.com/1007-9327/full/v20/i31/10895.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i31.10895

Full Article (PDF)	WJG-20-10895.pdf
Full Article (Word)	WJG-20-10895.doc
Manuscript File	9587-Review.docx
Answering Reviewers	9587-Answering Reviewers.pdf
Copyright License Agreement	9587-Copyright assignment.pdf
Peer-review Report	9587-Peer review.pdf
Scientific Misconduct Check	9587-CrossCheck.jpg
Scientific Editor Work List	9587-Scientific editor work list.pdf