Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	9781
Country	United States

Received	2014-02-27 21:12
Peer-Review Started	2014-02-28 17:14
To Make the First Decision	2014-03-27 10:55
Return for Revision	2014-04-02 20:52
Revised	2014-04-03 10:47
Second Decision	2014-10-27 16:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-10-27 17:01
Articles in Press	2014-10-27 17:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-06 08:26
Publish the Manuscript Online	2014-12-08 16:44

ISSN	1948-9366 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Diagnosis of inflammatory bowel disease: Potential role of molecular biometrics
Manuscript Source	Invited Manuscript
All Author List	Amosy E M’Koma
Funding Agency and Grant Number	Funding Agency Grant Number NIH R21DK095168 NIH U54MD007593 NIH UL1TR000445
Corresponding Author	Amosy E M’Koma, MD, MS, PhD, Assistant Professor of Surgery, Biochemistry and Cancer Biology, Department of Biochemistry and Cancer Biology, Meharry Medical College School of Medicine, 1005 Dr. D. B. Todd Jr. Blvd., Nashville, TN 37208-3599, United States. amkoma@mmc.edu
Key Words	Inflammatory bowel disease; Diagnosis; Advances and challenges; MALDI-MS/IMS; Molecular biometrics; Immunometrics
Core Tip	Pouch surgery (the restorative proctocolectomy and ileal pouch-anal anastomosis for the curative surgical treatment of ulcerative colitis and familial adenomatous polyposis) replaces the colon and rectum after proctocolectomy with a pouch constructed from the distal small bowel (ileum) and sutured to the anal canal above the dentate/pectinate line preserving the anal sphincters. The operation restores gut continuity, defecation, deferral, and discrimination, if the diagnosis is correct, which is unpredictable in 30% of the colonic-inflammatory bowel disease-patients. Mass spectrometry and imaging mass spectrometry are groundbreaking, non-invasive analytical technologies with the ability to directly measure individual molecular species in complex clinical specimens. These technologies provide quantitative and qualitative analysis of cellular systems, and allow differentiation between disease and normal molecules from the same organ. These characteristics offer diagnostic and prognostic value for clinical medicine.
Publish Date	2014-12-08 16:44
Citation	M’Koma AE. Diagnosis of inflammatory bowel disease: Potential role of molecular biometrics. World J Gastrointest Surg 2014; 6(11): 208-219
URL	http://www.wjgnet.com/1948-9366/full/v6/i11/208.htm
DOI	http://dx.doi.org/10.4240/wjgs.v6.i11.208

Full Article (PDF)	WJGS-6-208.pdf
Full Article (Word)	WJGS-6-208.doc
Manuscript File	9781-Review.docx
Answering Reviewers	9781-Answering reviewers.pdf
Copyright License Agreement	9781-Copyright assignment.pdf
Peer-review Report	9781-Peer review(s).pdf
Scientific Misconduct Check	9781-CrossCheck.jpg
Scientific Editor Work List	9781-Scientific editor work list.pdf