Publication Name	World Journal of Gastroenterology
Manuscript ID	9821
Country	Ireland

Received	2014-03-01 13:27
Peer-Review Started	2014-03-01 20:01
First Decision by Editorial Office Director
Return for Revision	2014-03-31 10:06
Revised	2014-04-18 00:00
Publication Fee Transferred
Second Decision by Editor	2014-05-26 21:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-05-26 21:55
Articles in Press	2014-05-26 22:08
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-10-08 19:48
Publish the Manuscript Online	2014-10-20 18:35

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Neurosciences
Manuscript Type	Topic Highlights
Article Title	Irritable bowel syndrome: A microbiome-gut-brain axis disorder?
Manuscript Source	Invited Manuscript
All Author List	Paul J Kennedy, John F Cryan, Timothy G Dinan and Gerard Clarke
Funding Agency and Grant Number	Funding Agency Grant Number Science Foundation Ireland SFI/12/RC/2272 Science Foundation Ireland 02/CE/B124 Science Foundation Ireland 07/CE/B1368 Health Research Board HRA_POR/2011/23 Brain and Behaviour Research Foundation 20771
Corresponding Author	Gerard Clarke, PhD, 1.15 Biosciences Institute, Department of Psychiatry, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland. g.clarke@ucc.ie
Key Words	Irritable bowel syndrome; Microbiome; Anxiety; Tryptophan; Abdominal pain; Gastrointestinal motility; Cognition
Core Tip	A dysregulated gut-brain axis may be responsible for the main features of irritable bowel syndrome (IBS). However, the role of the gut microbiota is an underappreciated but critical node in this construct. Numerous clinical studies have documented various alterations in the composition of the gut microbiota in IBS, indicating defects in stability and diversity of this virtual organ. Manipulation of the gut microbiome influences the symptom profile in IBS and clear mechanisms have been elucidated to explain these interactions. This has important clinical implications and may offer hope for future treatment options to alleviate the suffering caused by this debilitating disorder.
Publish Date	2014-10-20 18:35
Citation	Kennedy PJ, Cryan JF, Dinan TG, Clarke G. Irritable bowel syndrome: A microbiome-gut-brain axis disorder? World J Gastroenterol 2014; 20(39): 14105-14125
URL	http://www.wjgnet.com/1007-9327/full/v20/i39/14105.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i39.14105

Full Article (PDF)	WJG-20-14105.pdf
Full Article (Word)	WJG-20-14105.doc
Manuscript File	9821-Review.docx
Answering Reviewers	9821-Answering reviewers.pdf
Copyright License Agreement	9821-Copyright assignment.pdf
Peer-review Report	9821-Peer review.pdf
Scientific Misconduct Check	9821-CrossCheck.jpg
Scientific Editor Work List	9821-Scientific editor work list.pdf