Publication Name	World Journal of Gastroenterology
Manuscript ID	9899
Country	United States

Received	2014-03-03 15:39
Peer-Review Started	2014-03-03 18:15
To Make the First Decision	2014-04-28 13:55
Return for Revision	2014-05-23 08:33
Revised	2014-06-05 08:51
Second Decision	2014-07-25 08:02
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-25 09:30
Articles in Press	2014-07-25 10:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-10 18:58
Publish the Manuscript Online	2014-11-20 20:51

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Randomized Clinical Trial
Article Title	Lubiprostone vs Senna in postoperative orthopedic surgery patients with opioid-induced constipation: A double-blind, active-comparator trial
Manuscript Source	Unsolicited Manuscript
All Author List	Christina M Marciniak, Santiago Toledo, Jungwhalia Lee, Michael Jesselson, Jillian Bateman, Benjamin Grover and Joy Tierny
Funding Agency and Grant Number	Funding Agency Grant Number Takeda Pharmaceuticals North America, Inc
Corresponding Author	Christina M Marciniak, MD, Associate Professor, Department of Physical Medicine and Rehabilitation, School of Medicine, Northwestern University, 345 E Superior, Chicago, IL 60611, United States. cmarciniak@ric.org
Key Words	Constipation; Opioids; Lubiprostone; Senna; Orthopedics; Rehabilitation
Core Tip	Constipation is frequent in postoperative orthopedic patients treated with opioids. Opioid side effects are associated with poorer pain control, and thus may limit the ability to mobilize patients immediately following orthopedic surgery. There is very limited information comparing the efficacy and safety of pharmacologic interventions for opioid-induced constipation. In this study we found that two medications, lubiprostone and Senna, were associated with improvement in bowel-related symptoms in opioid-induced constipation in post-operative orthopedic patients, with no differences found between the two medications. Rescue bowel medications were frequently required by participants in both groups, indicating that multiple laxative medications may be required for constipation symptom control in this setting.
Publish Date	2014-11-20 20:51
Citation	Marciniak CM, Toledo S, Lee J, Jesselson M, Bateman J, Grover B, Tierny J. Lubiprostone vs Senna in postoperative orthopedic surgery patients with opioid-induced constipation: A double-blind, active-comparator trial. World J Gastroenterol 2014; 20(43): 16323-16333
URL	http://www.wjgnet.com/1007-9327/full/v20/i43/16323.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i43.16323

Full Article (PDF)	WJG-20-16323.pdf
Full Article (Word)	WJG-20-16323.doc
Manuscript File	9899-Review.docx
Answering Reviewers	9899-Answering reviewers.pdf
Biostatistics Review Certificate	Biostatistician_Review_Report_20140303055447.pdf
Copyright License Agreement	9899-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20140303055344.pdf
Peer-review Report	9899-Peer reviews.pdf
Scientific Misconduct Check	9899-CrossCheck.jpg
Scientific Editor Work List	9899-Scientific editor work list.pdf