Publication Name	World Journal of Gastroenterology
Manuscript ID	9904
Country	Saudi Arabia

Received	2014-03-03 21:32
Peer-Review Started	2014-03-04 08:24
To Make the First Decision	2014-03-27 20:59
Return for Revision	2014-03-31 10:22
Revised	2014-06-29 00:00
Second Decision	2014-07-11 17:01
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-11 17:20
Articles in Press	2014-07-11 17:34
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-08-03 20:11
Typeset the Manuscript	2014-10-26 15:44
Publish the Manuscript Online	2014-11-10 19:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Differential control of growth, apoptotic activity and gene expression in human colon cancer cells by extracts derived from medicinal herbs, Rhazya stricta and Zingiber officinale and their combination
Manuscript Source	Unsolicited Manuscript
All Author List	Ayman I Elkady, Rania Abd El Hamid Hussein and Osama A Abu-Zinadah
Funding Agency and Grant Number	Funding Agency Grant Number Deanship of Scientific Research, King Abdulaziz University 1431/130/159
Corresponding Author	Dr. Osama A Abu-Zinadah, Professor of Cell Biology and Histology, Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia. oaboznada@kau.edu.sa
Key Words	Apoptosis; Colorectal cancer; Oncogenes; Phytochemicals; Tumor suppressor proteins
Core Tip	Many medicinal plants represent a cornerstone for chemoprevention of colorectal cancer (CRC). Nonetheless, monotherapy with these agents has been unsatisfactory; therefore attention has turned towards therapies combining these plant-based extracts. In this study, we found that a combination of crude alkaloid and flavonoid extracts prepared from the medicinal herbs Rhazya stricta and Zingiber officinale, respectively, acted synergistically to suppress proliferation, induce apoptosis and modulate expression levels of cell cycle regulatory proteins in CRC cells. These results provide a foundation and rationale for exploiting these extracts for the prevention of CRC.
Publish Date	2014-11-10 19:10
Citation	Elkady AI, Hussein RAEH, Abu-Zinadah OA. Differential control of growth, apoptotic activity and gene expression in human colon cancer cells by extracts derived from medicinal herbs, Rhazya stricta and Zingiber officinale and their combination. World J Gastroenterol 2014; 20(41): 15275-15288
URL	http://www.wjgnet.com/1007-9327/full/v20/i41/15275.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i41.15275

Full Article (PDF)	WJG-20-15275.pdf
Full Article (Word)	WJG-20-15275.doc
Manuscript File	9904-Review.docx
Answering Reviewers	9904-Answering Reviewers.pdf
Copyright License Agreement	9904-Copyright Assignment.pdf
Non-Native Speakers of English Editing Certificate	Editing_Certificate_20140303132133.pdf
Peer-review Report	9904-Peer reviews.pdf
Scientific Misconduct Check	9904-CrossCheck.jpg
Scientific Editor Work List	9904-Scientific editor work list.pdf