Publication Name	World Journal of Gastroenterology
Manuscript ID	9945
Country	Palestine

Received	2014-03-05 20:13
Peer-Review Started	2014-03-06 09:03
First Decision by Editorial Office Director
Return for Revision	2014-03-31 10:21
Revised	2014-05-05 00:00
Publication Fee Transferred
Second Decision by Editor	2014-05-26 21:24
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-05-26 21:44
Articles in Press	2014-05-26 22:03
Edit the Manuscript by Language Editor	2014-08-06 20:10
Typeset the Manuscript	2014-08-24 19:08
Publish the Manuscript Online	2014-09-07 13:31

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Genetics & Heredity
Manuscript Type	Case Control Study
Article Title	Molecular detection of monocyte chemotactic protein-1 polymorphism in spontaneous bacterial peritonitis patients
Manuscript Source	Unsolicited Manuscript
All Author List	Maysa Kamal Salama, Dina Sabry, Mohamed AS Al-Ghussein, Rasha Ahmed, Sayed AbdAllah, Fatma Mohamed Taha, Wael Fathy, Miriam Safwat Wadie, Mona Nabih, Amr Abul-Fotouh and Tarneem Darwish
Funding Agency and Grant Number
Corresponding Author	Mohamed AS Al-Ghussein, PhD, Lecturer of Biochemistry and Medical Biochemistry, Biochemistry Department, Faculty of Pharmacy, Al-Azhar University, Talatini st., Gaza strip, Gaza 1277, Palestine. mohamedghussein@yahoo.com
Key Words	Monocyte chemotactic protein-1; Genotype; Spontaneous bacterial peritonitis; Liver cirrhosis; Ascites; Gene expression; Interleukin-10
Core Tip	Monocyte chemotactic protein-1 (MCP-1) polymorphism was investigated in hepatitis C virus (HCV) infected patients because of the higher susceptibility of cirrhosis and ascites patients to bacterial infections. MCP-1 secretion is up-regulated during chronic hepatitis and correlates with the severity of hepatic inflammation. Inheritance of MCP-1 GG genotype and MCP-1 G allele may predispose HCV infected patients to a more progressive disease course, while AG genotype may be a risk factor for spontaneous bacterial peritonitis (SBP) in patients with decompensated post-hepatitis C cirrhosis. MCP-1 expression and elevated IL-10 levels may be related to the development of SBP. HCV cirrhotic and SBP patients carrying the above genotypes should be under supervision and monitoring.
Publish Date	2014-09-07 13:31
Citation	Salama MK, Sabry D, Al-Ghussein MAS, Ahmed R, AbdAllah S, Taha FM, Fathy W, Wadie MS, Nabih M, Abul-Fotouh A, Darwish T. Molecular detection of monocyte chemotactic protein-1 polymorphism in spontaneous bacterial peritonitis patients. World J Gastroenterol 2014; 20(33): 11793-11799
URL	http://www.wjgnet.com/1007-9327/full/v20/i33/11793.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i33.11793

Full Article (PDF)	WJG-20-11793.pdf
Full Article (Word)	WJG-20-11793.doc
Manuscript File	9945-Review.docx
Answering Reviewers	9945-Answering reviewers.pdf
Copyright License Agreement	9945-Copyright assignment.pdf
Peer-review Report	9945-Peer review.pdf
Scientific Misconduct Check	9945-CrossCheck.jpg
Scientific Editor Work List	9945-Scientific editor work list.pdf