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12/18/2014 5:08:00 PM | Browse: 1323 | Download: 1389
Publication Name World Journal of Gastroenterology
Manuscript ID 9991
Country Netherlands
Received
2014-03-08 19:29
Peer-Review Started
2014-03-10 09:26
To Make the First Decision
2014-04-15 19:36
Return for Revision
2014-04-21 19:57
Revised
2014-04-30 01:38
Second Decision
2014-09-30 10:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-09-30 10:22
Articles in Press
2014-09-30 10:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-11-27 20:10
Publish the Manuscript Online
2014-12-18 17:08
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Hematopoietic stem cell transplantation for non-malignant gastrointestinal diseases
Manuscript Source Invited Manuscript
All Author List Abdulbaqi Al-toma, Petula Nijeboer, Gerd Bouma, Otto Visser and Chris JJ Mulder
Funding Agency and Grant Number
Corresponding Author Abdulbaqi Al-toma, MD, PhD, Gastroenterologist, Department of internal medicine and gastroenterology, St. Antonius hospital, Koekoeslaan 1, 3430 EM Nieuwegein, The Netherlands. a.altoma@antoniusziekenhuis.nl
Key Words Hematopoietic stem cell transplantation; Mesenchymal stem cells; Non-malignant gastrointestinal diseases; Celiac disease; Refractory celiac disease; Lymphoma; Crohn’s; Ulcerative colitis; Cirrhosis
Core Tip Hematopoietic stem cell transplantation (HSCT) can be used to treat malignant and non-malignant diseases. This therapeutic modality is based on using immunoablation followed by reinfusion of hematopoietic progenitor cells to regenerate naive T-lymphocytes. HSCT and mesenchymal SCT have been proved successful in treating refractory inflammatory conditions such as Crohn’s disease and refractory celiac disease type Ⅱ. The ultimate target of aggressively treating this type of celiac disease is to prevent development of lymphoma. Data in end-stage liver diseases are also encouraging.
Publish Date 2014-12-18 17:08
Citation Al-toma A, Nijeboer P, Bouma G, Visser O, Mulder CJJ. Hematopoietic stem cell transplantation for non-malignant gastrointestinal diseases. World J Gastroenterol 2014; 20(46): 17368-17375
URL http://www.wjgnet.com/1007-9327/full/v20/i46/17368.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i46.17368
Full Article (PDF) WJG-20-17368.pdf
Full Article (Word) WJG-20-17368.doc
Manuscript File 9991-Review.docx
Answering Reviewers 9991-Answering reviewers.pdf
Copyright License Agreement 9991-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 9991-Language certificate.pdf
Peer-review Report 9991-Peer review.pdf
Scientific Misconduct Check 9991-CorssCheck.jpg
Scientific Editor Work List 9991-Scientific editor work list.pdf