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12/20/2014 9:24:00 PM | Browse: 1250 | Download: 1321
Publication Name World Journal of Gastroenterology
Manuscript ID 10077
Country/Territory Italy
Received
2014-03-11 21:49
Peer-Review Started
2014-03-12 09:34
To Make the First Decision
2014-04-02 19:33
Return for Revision
2014-04-15 01:16
Revised
2014-05-22 23:40
Second Decision
2014-08-28 09:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-08-28 10:24
Articles in Press
2014-08-28 10:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-09-23 18:01
Typeset the Manuscript
2014-12-10 12:13
Publish the Manuscript Online
2014-12-20 19:42
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Pathogenesis of alcoholic liver disease: Role of oxidative metabolism
Manuscript Source Invited Manuscript
All Author List Elisabetta Ceni, Tommaso Mello and Andrea Galli
Funding Agency and Grant Number
Corresponding Author Andrea Galli, MD, PhD, Gastroenterology Unit, Department of Experimental and Clinical Biochemical Sciences, University of Florence, Viale Pieraccini 6, 50139, Firenze, Italy. a.galli@dfc.unifi.it
Key Words Alcohol metabolism; Acetaldehyde; Reactive oxygen species; Alcohol liver disease; Protein adducts; Hepatic stellate cells; Fibrosis; CYP2E1; Therapy
Core Tip The goal of this article is to review the mechanisms of alcohol-mediated toxicity in parenchymal and non-parenchymal cells of the liver. Specifically, we highlight the effect of oxidative-ethanol metabolites such as acetaldehyde and reactive oxidative species in the development of fat accumulation, fibrosis and deranged immune response.
Publish Date 2014-12-20 19:42
Citation Ceni E, Mello T, Galli A. Pathogenesis of alcoholic liver disease: Role of oxidative metabolism. World J Gastroenterol 2014; 20(47): 17756-17772
URL http://www.wjgnet.com/1007-9327/full/v20/i47/17756.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i47.17756
Full Article (PDF) WJG-20-17756.pdf
Full Article (Word) WJG-20-17756.doc
Manuscript File 10077-Review.doc
Answering Reviewers 10077-Answering reviewers.pdf
Copyright License Agreement 10077-Copyright assignment.pdf
Peer-review Report 10077-Peer review.pdf
Scientific Misconduct Check 10077-CorssCheck.jpg
Scientific Editor Work List 10077-Scientific editor work list.pdf