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1/18/2015 4:09:00 PM | Browse: 1179 | Download: 1284
Publication Name World Journal of Gastroenterology
Manuscript ID 10695
Country/Territory South Korea
Received
2014-04-15 08:47
Peer-Review Started
2014-04-15 16:03
To Make the First Decision
2014-05-13 20:10
Return for Revision
2014-05-21 08:28
Revised
2014-06-08 00:00
Second Decision
2014-07-11 17:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-07-11 17:12
Articles in Press
2014-07-11 17:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-08-09 20:34
Typeset the Manuscript
2014-12-27 20:27
Publish the Manuscript Online
2015-01-18 16:09
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Autobiography
Article Title Butein effects in colitis and interleukin-6/signal transducer and activator of transcription 3 expression
Manuscript Source Unsolicited Manuscript
All Author List Sehe Dong Lee, Jung Wan Choe, Beom Jae Lee, Myoung Hee Kang, Moon Kyung Joo, Ji Hoon Kim, Jong Eun Yeon, Jong-Jae Park, Jae Seon Kim and Young-Tae Bak
Funding Agency and Grant Number
Funding Agency Grant Number
National Research Foundation of Korea R1102452
Korea University K1220161
experimental techniques from the Core Laboratory for Convergent Translational Research of College of Medicine
Corresponding Author Beom Jae Lee, MD, PhD, Division of Gastroenterology, Department of Internal Medicine, Korea University Medical Center, 97 Gurodong-gil, Guro-gu, Seoul 152-703, South Korea. l85210@medimail.co.kr
Key Words Butein; Colitis; Inflammatory bowel disease; Interleukin-6/signal transducer and activator of transcription 3; Matrix metalloproteinase-9
Core Tip This study examined if butein, a naturally derived substance, has therapeutic effects in an animal model of inflammatory bowel disease, interleukin (IL)-10-/- mice. The results show that butein suppressed bowel inflammation and interfered with the IL-6/signal transducer and activator of transcription 3 and matrix metalloproteinase-9 pathways, suggesting that butein should be used to treat bowel inflammation-induced colon cancer. Although there have been several in vitro studies on tumor cells, there have been no in vivo studies examining the effect of butein on colitis in mice.
Publish Date 2015-01-18 16:09
Citation Lee SD, Choe JW, Lee BJ, Kang MH, Joo MK, Kim JH, Yeon JE, Park JJ, Kim JS, Bak YT. Butein effects in colitis and interleukin-6/signal transducer and activator of transcription 3 expression. World J Gastroenterol 2015; 21(2): 465-474
URL http://www.wjgnet.com/1007-9327/full/v21/i2/465.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i2.465
Full Article (PDF) WJG-21-465.pdf
Full Article (Word) WJG-21-465.doc
Manuscript File 10695-Review.docx
Answering Reviewers 10695-Answering reviewers.pdf
Copyright License Agreement 10695-Copyright assignment.pdf
Peer-review Report 10695-Peer review.pdf
Scientific Misconduct Check 10695-CrossCheck.jpg
Scientific Editor Work List 10695-Scientific editor work list.pdf