Publication Name	World Journal of Hepatology
Manuscript ID	11425
Country	Saudi Arabia

Received	2014-05-20 18:02
Peer-Review Started	2014-05-20 21:36
To Make the First Decision	2014-06-27 12:01
Return for Revision	2014-07-07 09:12
Revised	2014-11-26 00:00
Second Decision	2015-01-08 16:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-01-19 13:48
Articles in Press	2015-01-19 13:48
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-01-27 08:48
Typeset the Manuscript	2015-04-16 11:27
Publish the Manuscript Online	2015-05-01 19:01

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Non-alcoholic fatty liver disease: The diagnosis and management
Manuscript Source	Invited Manuscript
All Author List	Shehab M Abd El-Kader and Eman M Salah El-Den Ashmawy
Funding Agency and Grant Number
Corresponding Author	Shehab M Abd El-Kader, Professor, Department of Physical Therapy, Faculty of Applied Medical Sciences, King Abdulaziz University, PO Box 80324, Jeddah 21589, Saudi Arabia. profshehab@live.com
Key Words	Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Liver disease
Core Tip	Non-alcoholic fatty liver disease (NAFLD) is a serious and growing clinical problem due to the growing prevalence of obesity and overweight. Histologically, it resembles alcoholic liver injury but occurs in patients who deny significant alcohol consumption. NAFLD en-compasses a spectrum of conditions, ranging from benign hepatocellular steatosis to inflammatory non-alcoholic steatohepatitis, fibrosis, and cirrhosis. The majority of hepatocellular lipids are stored as triglycerides, but other lipid metabolites, such as free fatty acids, cholesterol, and phospholipids, may also be present and play a role in disease progression. NAFLD is associated with obesity and insulin resistance and is considered the hepatic manifestation of the metabolic syndrome, a combination of medical conditions including type 2 diabetes mellitus, hypertension, hyperlipidemia, and visceral adiposity. Confirmation of the diagnosis of NAFLD can usually be achieved by imaging studies; however, staging the disease requires a liver biopsy. Current treatment relies on weight loss and exercise, although various insulin-sensitizing agents, antioxidants and medications appear promising. The aim of this review is to highlight the current information regarding epidemiology, diagnosis, and management of NAFLD as well as new information about pathogenesis, diagnosis and management of this disease.
Publish Date	2015-05-01 19:01
Citation	Abd El-Kader SM, El-Den Ashmawy EMS. Non-alcoholic fatty liver disease: The diagnosis and management. World J Hepatol 2015; 7(6): 846-858
URL	http://www.wjgnet.com/1948-5182/full/v7/i6/846.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i6.846

Full Article (PDF)	WJH-7-846.pdf
Full Article (Word)	WJH-7-846.doc
Manuscript File	11425-Review.docx
Answering Reviewers	11425-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	11425-Conflict-of-interest statement.pdf
Copyright License Agreement	11425-Copyright assignment.pdf
Peer-review Report	11425-Peer review(s).pdf
Scientific Misconduct Check	11425-CrossCheck.jpg
Scientific Editor Work List	11425-Scientific editor work list.pdf