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5/1/2015 7:01:00 PM | Browse: 654 | Download: 713
Publication Name World Journal of Hepatology
Manuscript ID 11425
Country of Manuscript Source Saudi Arabia
Received
2014-05-20 18:02
Peer-Review Started
2014-05-20 21:36
To Make the First Decision
2014-06-27 12:01
Return for Revision
2014-07-07 09:12
Revised
2014-11-26 00:00
Second Decision
2015-01-08 16:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-01-19 13:48
Articles in Press
2015-01-19 13:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-01-27 08:48
Typeset the Manuscript
2015-04-16 11:27
Publish the Manuscript Online
2015-05-01 19:01
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Topic Highlights
Article Title Non-alcoholic fatty liver disease: The diagnosis and management
Manuscript Source Invited Manuscript
All Author List Shehab M Abd El-Kader and Eman M Salah El-Den Ashmawy
Funding Agency and Grant Number
Correspondence To Shehab M Abd El-Kader, Professor, Department of Physical Therapy, Faculty of Applied Medical Sciences, King Abdulaziz University, PO Box 80324, Jeddah 21589, Saudi Arabia. profshehab@live.com
Keywords Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Liver disease
Core Tip Non-alcoholic fatty liver disease (NAFLD) is a serious and growing clinical problem due to the growing prevalence of obesity and overweight. Histologically, it resembles alcoholic liver injury but occurs in patients who deny significant alcohol consumption. NAFLD en-compasses a spectrum of conditions, ranging from benign hepatocellular steatosis to inflammatory non-alcoholic steatohepatitis, fibrosis, and cirrhosis. The majority of hepatocellular lipids are stored as triglycerides, but other lipid metabolites, such as free fatty acids, cholesterol, and phospholipids, may also be present and play a role in disease progression. NAFLD is associated with obesity and insulin resistance and is considered the hepatic manifestation of the metabolic syndrome, a combination of medical conditions including type 2 diabetes mellitus, hypertension, hyperlipidemia, and visceral adiposity. Confirmation of the diagnosis of NAFLD can usually be achieved by imaging studies; however, staging the disease requires a liver biopsy. Current treatment relies on weight loss and exercise, although various insulin-sensitizing agents, antioxidants and medications appear promising. The aim of this review is to highlight the current information regarding epidemiology, diagnosis, and management of NAFLD as well as new information about pathogenesis, diagnosis and management of this disease.
Publish Date 2015-05-01 19:01
Citation Abd El-Kader SM, El-Den Ashmawy EMS. Non-alcoholic fatty liver disease: The diagnosis and management. World J Hepatol 2015; 7(6): 846-858
Url http://www.wjgnet.com/1948-5182/full/v7/i6/846.htm
DOI http://dx.doi.org/10.4254/wjh.v7.i6.846
Full Article (PDF) WJH-7-846.pdf
Full Article (Word) WJH-7-846.doc
Manuscript File 11425-Review.docx
Answering Reviewers 11425-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form 11425-Conflict-of-interest statement.pdf
Copyright License Agreement 11425-Copyright assignment.pdf
Peer-review Report 11425-Peer review(s).pdf
Scientific Misconduct Check 11425-CrossCheck.jpg
Scientific Editor Work List 11425-Scientific editor work list.pdf