Publication Name	World Journal of Clinical Oncology
Manuscript ID	11450
Country	United States

Received	2014-05-22 09:18
Peer-Review Started	2014-05-23 23:12
To Make the First Decision	2014-06-27 12:00
Return for Revision	2014-07-07 09:39
Revised	2014-07-19 01:48
Second Decision	2014-09-10 13:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-09-10 14:03
Articles in Press	2014-09-10 14:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-18 09:07
Publish the Manuscript Online	2014-12-11 14:23

ISSN	2218-4333 (online)
Open Access
Copyright
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Category	Cell Biology
Manuscript Type	Topic Highlights
Article Title	Nexus of signaling and endocytosis in oncogenesis driven by non-small cell lung cancer-associated epidermal growth factor receptor mutants
Manuscript Source	Invited Manuscript
All Author List	Byung Min Chung, Eric Tom, Neha Zutshi, Timothy Alan Bielecki, Vimla Band and Hamid Band
Funding Agency and Grant Number	Funding Agency Grant Number NIH CA99163(to Band H) NIH CA87986(to Band H) NIH CA105489(to Band H) NIH CA116552(to Band H) Department of Defense W81WH-11-1-0167(to Band H) NIH CA96844(to Band V) NIH CA144027(to Band V) Department of Defense W81XWH-07-1-0351(to Band V) Department of Defense W81XWH-11-1-0171(to Band V) Nebraska Department of Health and Human Services LB-506 No. 2014-01(to Band H) NCI Core Support Grant to the UNMC Buffett Cancer Center NCI Institutional Cancer Biology Training CA009476(to Bielecki TA)
Corresponding Author	Hamid Band, MD, PhD, Elizabeth Bruce Professor of Cancer Research, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 4400 Emile St, Omaha, NE 68198-5950, United States. hband@unmc.edu
Key Words	Non-small cell lung cancer; Epidermal growth factor receptor; Signaling; Endocytosis; Src; Cbl; Ubiquitination
Core Tip	Since their discovery ten years ago, much work has revealed the signaling properties of non-small cell lung cancer-associated mutant epidermal growth factor receptors (EGFRs). While therapeutic options for patients harboring mutants have emerged, these are beset with rapid development of resistance, making it critical that mutant EGFR biology be better understood to design more effective therapies. Emerging data suggests that mutant EGFRs exhibit altered endocytic trafficking, a process critical for the regulation of EGFR signaling. Deregulated endocytic traffic appears to enable mutant EGFRs to activate oncogenic signaling pathways. This review highlights the signaling and endocytic trafficking of mutant EGFR and the intimate link between the two processes.
Publish Date	2014-12-11 14:23
Citation	Chung BM, Tom E, Zutshi N, Bielecki TA, Band V, Band H. Nexus of signaling and endocytosis in oncogenesis driven by non-small cell lung cancer-associated epidermal growth factor receptor mutants. World J Clin Oncol 2014; 5(5): 806-823
URL	http://www.wjgnet.com/2218-4333/full/v5/i5/806.htm
DOI	http://dx.doi.org/10.5306/wjco.v5.i5.806

Full Article (PDF)	WJCO-5-806.pdf
Full Article (Word)	WJCO-5-806.doc
Manuscript File	11450-Review.docx
Answering Reviewers	11450-Answering reviewers.pdf
Copyright License Agreement	11450-Copyright assignment.pdf
Peer-review Report	11450-Peer review(s).pdf
Scientific Misconduct Check	11450-CrossCheck.jpg
Scientific Editor Work List	11450-Scientific editor work list.pdf