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8/20/2015 8:49:00 AM | Browse: 855 | Download: 752
Publication Name World Journal of Hematology
Manuscript ID 12129
Country/Territory Netherlands
2014-06-23 16:23
Peer-Review Started
2014-06-23 19:59
To Make the First Decision
2014-08-14 14:39
Return for Revision
2014-08-18 09:39
2014-11-15 00:00
Second Decision
2015-04-20 11:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-04-30 11:23
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-08-06 18:07
Publish the Manuscript Online
2015-08-20 08:49
ISSN 2218-6204 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Hematology
Manuscript Type Review
Article Title European vs 2015-World Health Organization clinical molecular and pathological classification of myeloproliferative neoplasms
Manuscript Source Unsolicited Manuscript
All Author List Jan Jacques Michiels, Fransje Valster, Jenne Wielenga, Katrien Schelfout and Hendrik De Raeve
Funding Agency and Grant Number
Corresponding Author Jan Jacques Michiels, MD, PhD, Investigator, Senior Internist, International Hematology and Bloodcoagulation Research Center, Goodheart Institute and Foundation in Nature Medicine, European Working Group on Myeloproliferative Neoplasms, Erasmus Tower, Veenmos 13, 3069 AT Rotterdam, The Netherlands. goodheartcenter@upcmail.nl
Key Words Myeloproliferative disorders; Essential thrombocythemia; Primary megakaryocytic granulocytic myeloproliferation; Myelofibrosis; JAK2V617F mutation; MPL515 mutation; Calreticulin mutation; JAK2 wild type; Myeloproliferative neoplasm; Bone marrow pathology; Polycythemia vera
Core Tip The 2015 World Health Organization-Clinical Molecular and Pathological criteria define three pheno-types of JAK2V617F mutated myeloproliferative neoplasms (MPNs) essential thrombocythemia (ET), prodromal polycythemia vera (PV), prodromal PV, hyper-cellular megakaryocytic-granulocytic myelo-proliferation and classical PV vs the JAK2 exon 12 mutated idiopathic eryhrocythemia and PV. MPL515 mutated JAK2 wild type ET and myelofibrosis is a distinct thrombocythemia without features of PV in blood and bone marrow. Calreticulin mutated JAK2/MPL wild type ET and myelofibrosis is the third thrombocythemia entity with characteristic features of primary megakaryocytic granulocytic myeloproliferation in the bone marrow, which are not seen in JAK2 and MPL mutated MPNs. MPN disease burden is best reflected by the degree of anemia and splenomegaly on top of mutation allele burden, bone marrow cellularity and increase of reticulin fibrosis.
Publish Date 2015-08-20 08:49
Citation Michiels JJ, Valster F, Wielenga J, Schelfout K, De Raeve H. European vs 2015-World Health Organization clinical molecular and pathological classification of myeloproliferative neoplasms. World J Hematol 2015; 4(3): 16-53
URL http://www.wjgnet.com/2218-6204/full/v4/i3/16.htm
DOI http://dx.doi.org/10.5315/wjh.v4.i3.16
Full Article (PDF) WJH-4-16.pdf
Full Article (Word) WJH-4-16.doc
Manuscript File 12129-Review.docx
Answering Reviewers 12129-Answering reviewers.pdf
Audio Core Tip 12129-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 12129-Conflict-of-interest statement.pdf
Copyright License Agreement 12129-Copyright assignment.pdf
Peer-review Report 12129-Peer-review(s).pdf
Scientific Misconduct Check 12129-Scientific misconduct check.pdf
Scientific Editor Work List 12129-Scientific editor work list.pdf