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2/11/2015 5:56:00 PM | Browse: 998 | Download: 876
Publication Name World Journal of Gastroenterology
Manuscript ID 13115
Country/Territory Italy
Received
2014-08-06 08:20
Peer-Review Started
2014-08-06 13:42
To Make the First Decision
2014-09-15 16:11
Return for Revision
2014-09-22 08:24
Revised
2014-10-03 23:11
Second Decision
2014-11-10 16:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-11-19 09:26
Articles in Press
2014-11-19 09:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-01-28 10:29
Publish the Manuscript Online
2015-02-11 17:56
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Prospective Study
Article Title Human cytomegalovirus and Epstein-Barr virus infection in inflammatory bowel disease: Need for mucosal viral load measurement
Manuscript Source Invited Manuscript
All Author List Rachele Ciccocioppo, Francesca Racca, Stefania Paolucci, Giulia Campanini, Lodovica Pozzi, Elena Betti, Roberta Riboni, Alessandro Vanoli, Fausto Baldanti and Gino Roberto Corazza
Funding Agency and Grant Number
Funding Agency Grant Number
Fondazione IRCCS Policlinico San Matteo 8064409(in part)
Corresponding Author Rachele Ciccocioppo, MD, Centre for the Study and Cure of Inflammatory Bowel Disease, Clinica Medica I, IRCCS San Matteo Hospital Foundation, University of Pavia, Piazzale Golgi 19, 27100 Pavia, Italy. rachele.ciccocioppo@unipv.it
Key Words Inflammatory bowel disease; quantitative real-time polymerase chain reaction; steroid therapy; refractory; viral infection
Core Tip This study investigated the presence of human Cytomegalovirus and Epstein-Barr virus (EBV) infection in patients with refractory and non-refractory inflammatory bowel disease (IBD). We identified qu?antitative real-time polymerase chain reaction assay of mucosal specimens as the best diagnostic technique. This allowed us to distinguish between viral colitis and infection through the identification of a cutoff value. All refractory IBD patients carried the highest mucosal viral loads, which correlated with the severity of mucosal damage and endoscopic activity. EBV infection was the most prevalent. Finally, steroid therapy was identified as a significant risk factor for viral colitis.
Publish Date 2015-02-11 17:56
Citation Ciccocioppo R, Racca F, Paolucci S, Campanini G, Pozzi L, Betti E, Riboni R, Vanoli A, Baldanti F, Corazza GR. human cytomegalovirus and epstein-barr virus infection in inflammatory bowel disease: need for mucosal viral load measurement. World J Gastroenterol 2015; 21(6): 1915-1926
URL http://www.wjgnet.com/1007-9327/full/v21/i6/1915.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i6.1915
Full Article (PDF) WJG-21-1915.pdf
Full Article (Word) WJG-21-1915.doc
Manuscript File 13115-Review.docx
Answering Reviewers 13115-Answering reviewers.pdf
Copyright License Agreement 13115-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 13115-Language certificate.pdf
Peer-review Report 13115-Peer review(s).pdf
Scientific Misconduct Check 13115-CrossCheck.jpg
Scientific Editor Work List 13115-Scientific editor work list.pdf