| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Eugene Chang, Lisa Kim, Se Eun Park, Eun-Jung Rhee, Won-Young Lee, Ki-Won Oh, Sung-Woo Park and Cheol-Young Park |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Samsung Biomedical Research Institute |
SBRI C-B1-111-3 |
| National Research Foundation of Korea |
2012R1A1A2009143/2013027171 |
| Korean Diabetes Association |
2014S-1(to Park CY) |
|
| Corresponding Author |
Cheol-Young Park, MD, PhD, Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, No. 108, Pyung-Dong, Jongno-Ku, Seoul 110-746, South Korea. cydoctor@chol.com |
| Key Words |
Autophagy; Ezetimibe; Hepatic steatosis; Nonalcoholic fatty liver disease |
| Core Tip |
As an anti-hypercholesterolemia drug, ezetimibe is reported to improve metabolic disorders. Moreover, the hepatic expression of Niemann-Pick C1-like 1 protein, the target of ezetimibe, has led to increased interest in the effects, which have not been fully delineated, of ezetimibe on the liver. In the current study, ezetimibe treatment improved hepatic fat accumulation, which was accompanied by the induction of hepatic autophagy in obese and diabetic rats. In addition, in vitro hepatocytes treated with an inhibitor of autophagy showed that ezetimibe-induced autophagy resulted from an increase in autophagic flux. Therefore, ezetimibe-increased autophagy flux may play an important role in the improvement of hepatic steatosis. |
| Publish Date |
2015-07-08 12:01 |
| Citation |
Chang E, Kim L, Park SE, Rhee EJ, Lee WY, Oh KW, Park SW, Park CY. Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. World J Gastroenterol 2015; 21(25): 7754-7763 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i25/7754.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i25.7754 |
