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7/8/2015 12:00:00 PM | Browse: 1313 | Download: 2087
Publication Name World Journal of Gastroenterology
Manuscript ID 13763
Country/Territory South Korea
Received
2014-09-01 09:05
Peer-Review Started
2014-09-01 11:23
To Make the First Decision
2014-09-27 15:38
Return for Revision
2014-10-10 16:00
Revised
2014-11-18 00:00
Second Decision
2014-12-25 09:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-01-08 17:14
Articles in Press
2015-01-08 17:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-06-17 11:30
Publish the Manuscript Online
2015-07-08 12:01
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats
Manuscript Source Unsolicited Manuscript
All Author List Eugene Chang, Lisa Kim, Se Eun Park, Eun-Jung Rhee, Won-Young Lee, Ki-Won Oh, Sung-Woo Park and Cheol-Young Park
Funding Agency and Grant Number
Funding Agency Grant Number
Samsung Biomedical Research Institute SBRI C-B1-111-3
National Research Foundation of Korea 2012R1A1A2009143/2013027171
Korean Diabetes Association 2014S-1(to Park CY)
Corresponding Author Cheol-Young Park, MD, PhD, Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, No. 108, Pyung-Dong, Jongno-Ku, Seoul 110-746, South Korea. cydoctor@chol.com
Key Words Autophagy; Ezetimibe; Hepatic steatosis; Nonalcoholic fatty liver disease
Core Tip As an anti-hypercholesterolemia drug, ezetimibe is reported to improve metabolic disorders. Moreover, the hepatic expression of Niemann-Pick C1-like 1 protein, the target of ezetimibe, has led to increased interest in the effects, which have not been fully delineated, of ezetimibe on the liver. In the current study, ezetimibe treatment improved hepatic fat accumulation, which was accompanied by the induction of hepatic autophagy in obese and diabetic rats. In addition, in vitro hepatocytes treated with an inhibitor of autophagy showed that ezetimibe-induced autophagy resulted from an increase in autophagic flux. Therefore, ezetimibe-increased autophagy flux may play an important role in the improvement of hepatic steatosis.
Publish Date 2015-07-08 12:01
Citation Chang E, Kim L, Park SE, Rhee EJ, Lee WY, Oh KW, Park SW, Park CY. Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. World J Gastroenterol 2015; 21(25): 7754-7763
URL http://www.wjgnet.com/1007-9327/full/v21/i25/7754.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i25.7754
Full Article (PDF) WJG-21-7754.pdf
Full Article (Word) WJG-21-7754.doc
Manuscript File 13763-Review.docx
Answering Reviewers 13763-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form 13763-Conflict-of-interest statement.pdf
Copyright License Agreement 13763-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 13763-Institutional animal care and use committee.pdf
Institutional Review Board Approval Form or Document 13763-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 13763-Language certificate.pdf
Peer-review Report 13763-Peer review(s).pdf
Scientific Misconduct Check 13763-CrossCheck.jpg
Scientific Editor Work List 13763-Scientific editor work list.pdf