| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Prognostic roles of preoperative α-fetoprotein and des-γ-carboxy prothrombin in hepatocellular carcinoma patients
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Makoto Meguro, Toru Mizuguchi, Toshihiko Nishidate, Kenji Okita, Masayuki Ishii, Shigenori Ota, Tomomi Ueki, Emi Akizuki and Koichi Hirata |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan |
24791437 |
| Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan |
26461920 (to Meguro M) |
| Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan |
13377023 (to Hirata K) |
| Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan |
23591993 (to Mizuguchi T) |
| Yuasa Memorial Foundation |
to Mizuguchi T |
|
| Corresponding Author |
Makoto Meguro, MD, PhD, Department of Surgery, Surgical Oncology and Science, Sapporo Medical University School of Medicine, South-1, West-16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan. meguro@sapmed.ac.jp |
| Key Words |
Hepatocellular carcinoma; Hepatitis B; Hepatitis C; Des-γ-carboxy prothrombin; α-fetoprotein |
| Core Tip |
There is no consensus regarding using cutoff levels of tumor markers to predict survival and recurrence after hepatectomy for hepatocellular carcinoma. Furthermore, the prognostic characteristics of these tumor markers according to hepatitis type remain unclear. The α-fetoprotein (AFP) cutoff level for recurrence within 2 years after surgery was 21.0 ng/mL in the hepatitis C virus (HCV) group compared with 529.8 ng/mL in the hepatitis B virus (HBV) group. Furthermore, patients in the HBV group with high levels of either AFP or des-γ-carboxy prothrombin (DCP) had poor prognoses, as did those patients with high levels of both tumor markers. In contrast, only those patients in the HCV group who had high levels of both AFP and DCP had poor prognoses. We believe that to predict prognosis, preoperative levels of tumor markers should be distinguished and assessed according to the type of viral hepatitis. |
| Publish Date |
2015-04-27 16:22 |
| Citation |
Meguro M, Mizuguchi T, Nishidate T, Okita K, Ishii M, Ota S, Ueki T, Akizuki E, Hirata K. Prognostic roles of preoperative α-fetoprotein and des-γ-carboxy prothrombin in hepatocellular carcinoma patients. World J Gastroenterol 2015; 21(16): 4933-4945 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i16/4933.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i16.4933 |
