BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
4/27/2015 4:29:00 PM | Browse: 539 | Download: 745
Publication Name World Journal of Gastroenterology
Manuscript ID 14387
Country/Territory Japan
Received
2014-09-30 16:15
Peer-Review Started
2014-09-30 17:42
To Make the First Decision
2014-10-29 14:58
Return for Revision
2014-11-03 13:56
Revised
2014-11-11 21:33
Second Decision
2014-12-08 14:46
Accepted by Journal Editor-in-Chief
2014-12-10 09:40
Accepted by Company Editor-in-Chief
2014-12-16 10:20
Articles in Press
2014-12-16 10:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-04-14 20:07
Publish the Manuscript Online
2015-04-27 16:22
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Retrospective Study
Article Title Prognostic roles of preoperative α-fetoprotein and des-γ-carboxy prothrombin in hepatocellular carcinoma patients
Manuscript Source Invited Manuscript
All Author List Makoto Meguro, Toru Mizuguchi, Toshihiko Nishidate, Kenji Okita, Masayuki Ishii, Shigenori Ota, Tomomi Ueki, Emi Akizuki and Koichi Hirata
Funding Agency and Grant Number
Funding Agency Grant Number
Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan 24791437
Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan 26461920 (to Meguro M)
Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan 13377023 (to Hirata K)
Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan 23591993 (to Mizuguchi T)
Yuasa Memorial Foundation to Mizuguchi T
Corresponding author Makoto Meguro, MD, PhD, Department of Surgery, Surgical Oncology and Science, Sapporo Medical University School of Medicine, South-1, West-16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan. meguro@sapmed.ac.jp
Keywords Hepatocellular carcinoma; Hepatitis B; Hepatitis C; Des-γ-carboxy prothrombin; α-fetoprotein
Core Tip There is no consensus regarding using cutoff levels of tumor markers to predict survival and recurrence after hepatectomy for hepatocellular carcinoma. Furthermore, the prognostic characteristics of these tumor markers according to hepatitis type remain unclear. The α-fetoprotein (AFP) cutoff level for recurrence within 2 years after surgery was 21.0 ng/mL in the hepatitis C virus (HCV) group compared with 529.8 ng/mL in the hepatitis B virus (HBV) group. Furthermore, patients in the HBV group with high levels of either AFP or des-γ-carboxy prothrombin (DCP) had poor prognoses, as did those patients with high levels of both tumor markers. In contrast, only those patients in the HCV group who had high levels of both AFP and DCP had poor prognoses. We believe that to predict prognosis, preoperative levels of tumor markers should be distinguished and assessed according to the type of viral hepatitis.
Publish Date 2015-04-27 16:22
Citation Meguro M, Mizuguchi T, Nishidate T, Okita K, Ishii M, Ota S, Ueki T, Akizuki E, Hirata K. Prognostic roles of preoperative α-fetoprotein and des-γ-carboxy prothrombin in hepatocellular carcinoma patients. World J Gastroenterol 2015; 21(16): 4933-4945
Url http://www.wjgnet.com/1007-9327/full/v21/i16/4933.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i16.4933
Full Article (PDF) WJG-21-4933.pdf
Full Article (Word) WJG-21-4933.doc
Manuscript File 14387-Review.docx
Answering Reviewers 14387-Answering reviewers.pdf
Biostatistics Review Certificate 14387-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 14387-Conflict-of-interest statement.pdf
Copyright License Agreement 14387-Copyright assignment.pdf
Data Sharing Statement 14387-Data sharing statement.pdf
Institutional Review Board Approval Form or Document 14387-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 14387-Language certificate.pdf
Peer-review Report 14387-Peer review(s).pdf
Scientific Misconduct Check 14387-CrossCheck.jpg
Scientific Editor Work List 14387-Scientific editor work list.pdf