| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Chronic hepatitis C virus infection and neurological and psychiatric disorders: An overview
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Luigi Elio Adinolfi, Riccardo Nevola, Giacomo Lus, Luciano Restivo, Barbara Guerrera, Ciro Romano, Rosa Zampino, Luca Rinaldi, Ausilia Sellitto, Mauro Giordano and Aldo Marrone |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Regione Campania, Italy |
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| Corresponding Author |
Luigi Elio Adinolfi, MD, Professor, Director of Internal Medicine, Clinical Hospital of Marcianise, Second University of Naples, ASL Caserta, Rione Santella, 81025 Marcianise (CE), Italy. luigielio.adinolfi@unina2.it |
| Key Words |
Hepatitis C virus; Neurological disorders; Psychiatric disorders; Stroke; Inflammation |
| Core Tip |
High prevalence of neuropsychiatric disorders has been reported in chronic hepatitis C virus (HCV) infected patients. Cerebrovascular disease, brain in?flammatory disorders, cognitive symptoms, peripheral neuropathy, and psychiatric disturbs are among the multifaceted clinical manifestations occurring during chronic HCV infection. HCV induces neurological and psychiatric symptoms through several complex and as yet unclear mechanisms, including direct brain neurotoxicity, metabolic and neurotransmitter pathway derangement, inflammation, and immune-mediated responses. Knowledge of HCV-associated neuropsychiatric manifestations and pathogenic mechanisms is paramount to correctly understand the whole clinical picture and to institute an appropriate treatment. Evidence suggests improvement of neurological symptoms following specific antiviral therapy. |
| Publish Date |
2015-02-28 17:07 |
| Citation |
Adinolfi LE, Nevola R, Lus G, Restivo L, Guerrera B, Romano C, Zampino R, Rinaldi L, Sellitto A, Giordano M, Marrone A. Chronic hepatitis C virus infection and neurological and psychiatric disorders: An overview. World J Gastroenterol 2015; 21(8): 2269-2280 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i8/2269.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i8.2269 |
