Publication Name	World Journal of Gastroenterology
Manuscript ID	14422
Country	Japan

Received	2014-10-03 12:14
Peer-Review Started	2014-10-03 21:58
To Make the First Decision	2014-11-14 18:50
Return for Revision	2014-11-18 19:20
Revised	2014-11-21 18:52
Second Decision	2015-01-12 13:59
Accepted by Journal Editor-in-Chief	2015-01-13 03:01
Accepted by Company Editor-in-Chief	2015-01-16 18:03
Articles in Press	2015-01-16 18:23
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-02-05 01:51
Typeset the Manuscript	2015-04-14 10:05
Publish the Manuscript Online	2015-04-27 16:22

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Pathophysiology of functional heartburn based on Rome Ⅲ criteria in Japanese patients
Manuscript Source	Unsolicited Manuscript
All Author List	Yasuhiro Tamura, Yasushi Funaki, Shinya Izawa, Akihito Iida, Yoshiharu Yamaguchi, Kazunori Adachi, Naotaka Ogasawara, Makoto Sasaki, Hiroshi Kaneko and Kunio Kasugai
Funding Agency and Grant Number
Corresponding Author	Yasushi Funaki, MD, Department of Gastroenterology, Division of Internal Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan. momomaru@aichi-med-u.ac.jp
Key Words	Functional heartburn; endoscopy-negative reflux disease; proton pump inhibitor-resistant; Rome Ⅲ criteria; 24-h multichannel intraluminal impedance-pH testing
Core Tip	The Rome Ⅲ criteria define functional heartburn (FH) by normal esophageal acid exposure time, with no relationship between symptoms and reflux, and no response to proton pump inhibitor (PPI) treatment. However, in Japanese clinical practice, PPI-refractory non-erosive reflux disease is often treated as FH, thought the pathophysiology of these diseases is not clear. In this study, we found no differences in the clinical characteristics of FH and PPI-refractory endoscopy-negative reflux disease, and recommend using manometry and 24-h multichannel intraluminal impedance-pH testing to differentiate between these two conditions.
Publish Date	2015-04-27 16:22
Citation	Tamura Y, Funaki Y, Izawa S, Iida A, Yamaguchi Y, Adachi K, Ogasawara N, Sasaki M, Kaneko H, Kasugai K. Pathophysiology of functional heartburn based on Rome Ⅲ criteria in Japanese patients. World J Gastroenterol 2015; 21(16): 5009-5016
URL	http://www.wjgnet.com/1007-9327/full/v21/i16/5009.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i16.5009

Full Article (PDF)	WJG-21-5009.pdf
Full Article (Word)	WJG-21-5009.doc
Manuscript File	14422-Review.docx
Answering Reviewers	14422-Answering reivewers.pdf
Biostatistics Review Certificate	14422-Biostatistics statement.pdf
Clinical Trial Registration Statement	14422-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	14422-Conflict-of-interest statement.pdf
Copyright License Agreement	14422-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	14422-Clinical trial registration statement.pdf
Institutional Review Board Approval Form or Document	14422-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	14422-Language certificate.pdf
Peer-review Report	14422-Peer-review(s).pdf
Scientific Misconduct Check	14422-CrossCheck.jpg
Scientific Editor Work List	14422-Scientific editor work list.pdf