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4/27/2015 4:29:00 PM | Browse: 441 | Download: 632
Publication Name World Journal of Gastroenterology
Manuscript ID 14422
Country/Territory Japan
Received
2014-10-03 12:14
Peer-Review Started
2014-10-03 21:58
To Make the First Decision
2014-11-14 18:50
Return for Revision
2014-11-18 19:20
Revised
2014-11-21 18:52
Second Decision
2015-01-12 13:59
Accepted by Journal Editor-in-Chief
2015-01-13 03:01
Accepted by Company Editor-in-Chief
2015-01-16 18:03
Articles in Press
2015-01-16 18:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-02-05 01:51
Typeset the Manuscript
2015-04-14 10:05
Publish the Manuscript Online
2015-04-27 16:22
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Prospective Study
Article Title Pathophysiology of functional heartburn based on Rome Ⅲ criteria in Japanese patients
Manuscript Source Unsolicited Manuscript
All Author List Yasuhiro Tamura, Yasushi Funaki, Shinya Izawa, Akihito Iida, Yoshiharu Yamaguchi, Kazunori Adachi, Naotaka Ogasawara, Makoto Sasaki, Hiroshi Kaneko and Kunio Kasugai
Funding Agency and Grant Number
Corresponding author Yasushi Funaki, MD, Department of Gastroenterology, Division of Internal Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan. momomaru@aichi-med-u.ac.jp
Key Words Functional heartburn; endoscopy-negative reflux disease; proton pump inhibitor-resistant; Rome Ⅲ criteria; 24-h multichannel intraluminal impedance-pH testing
Core Tip The Rome Ⅲ criteria define functional heartburn (FH) by normal esophageal acid exposure time, with no relationship between symptoms and reflux, and no response to proton pump inhibitor (PPI) treatment. However, in Japanese clinical practice, PPI-refractory non-erosive reflux disease is often treated as FH, thought the pathophysiology of these diseases is not clear. In this study, we found no differences in the clinical characteristics of FH and PPI-refractory endoscopy-negative reflux disease, and recommend using manometry and 24-h multichannel intraluminal impedance-pH testing to differentiate between these two conditions.
Publish Date 2015-04-27 16:22
Citation Tamura Y, Funaki Y, Izawa S, Iida A, Yamaguchi Y, Adachi K, Ogasawara N, Sasaki M, Kaneko H, Kasugai K. Pathophysiology of functional heartburn based on Rome Ⅲ criteria in Japanese patients. World J Gastroenterol 2015; 21(16): 5009-5016
Url http://www.wjgnet.com/1007-9327/full/v21/i16/5009.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i16.5009
Full Article (PDF) WJG-21-5009.pdf
Full Article (Word) WJG-21-5009.doc
Manuscript File 14422-Review.docx
Answering Reviewers 14422-Answering reivewers.pdf
Biostatistics Review Certificate 14422-Biostatistics statement.pdf
Clinical Trial Registration Statement 14422-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form 14422-Conflict-of-interest statement.pdf
Copyright License Agreement 14422-Copyright assignment.pdf
Data Sharing Statement 14422-Data sharing statement.pdf
Signed Informed Consent Form(s) or Document(s) 14422-Clinical trial registration statement.pdf
Institutional Review Board Approval Form or Document 14422-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 14422-Language certificate.pdf
Peer-review Report 14422-Peer-review(s).pdf
Scientific Misconduct Check 14422-CrossCheck.jpg
Scientific Editor Work List 14422-Scientific editor work list.pdf