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5/21/2015 2:15:00 PM | Browse: 647 | Download: 695
Publication Name World Journal of Experimental Medicine
Manuscript ID 14444
Country of Manuscript Source Venezuela
Received
2014-10-04 14:57
Peer-Review Started
2014-10-05 11:07
To Make the First Decision
2014-11-14 18:42
Return for Revision
2014-11-20 08:54
Revised
2014-12-05 09:09
Second Decision
2015-03-11 13:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-03-20 10:37
Articles in Press
2015-03-20 10:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-04-22 16:07
Publish the Manuscript Online
2015-05-21 14:15
ISSN 2220-315x (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Review
Article Title Role of the Wnt/β-catenin pathway in gastric cancer: An in-depth literature review
Manuscript Source Invited Manuscript
All Author List Miguel Angel Chiurillo
Funding Agency and Grant Number
Corresponding author Miguel Angel Chiurillo, MD, PhD, Laboratorio de Genética Molecular “Dr. Yunis-Turbay”, Decanato de Ciencias de la Salud, Universidad Centroccidental Lisandro Alvarado, Barquisimeto 3001, Estado Lara, Venezuela. mchiurillo@ucla.edu.ve
Keywords Gastric cancer; Wnt; β-catenin; Oncogene; Tumor suppressor; Epigenetics; Helicobacter pylori; Adenomatous polyposis coli
Core Tip Available data indicate that Wnt signaling substantially impacts gastric tumorigenesis, prognosis, and resistance to therapy. Loss of Wnt signaling inhibitors (such as APC) by promoter hypermethylation, allelic loss or other mechanisms appear to be particularly important in activating Wnt/β-catenin signaling. Gastric cancer is an entity characterized by its heterogeneity in various aspects, and much remains to be learned about the molecular aspects that determine the process of cancer development in this organ. The role that plays the canonical Wnt pathway in gastric carcinogenesis is reviewed.
Publish Date 2015-05-21 14:15
Citation Chiurillo MA. Role of the Wnt/β-catenin pathway in gastric cancer: An in-depth literature review. World J Exp Med 2015; 5(2): 84-102
Url http://www.wjgnet.com/2220-315X/full/v5/i2/84.htm
DOI http://dx.doi.org/10.5493/wjem.v5.i2.84
Full Article (PDF) WJEM-5-84.pdf
Full Article (Word) WJEM-5-84.doc
Manuscript File 14444-Review.docx
Answering Reviewers 14444-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form 14444-Conflict-of-interest statement.pdf
Copyright License Agreement 14444-Copyright assignment.pdf
Peer-review Report 14444-Peer-review(s).pdf
Scientific Misconduct Check 14444-Scientific misconduct check.pdf
Scientific Editor Work List 14444-Scientific editor work list.pdf