Publication Name	World Journal of Experimental Medicine
Manuscript ID	15457
Country	Germany

Received	2014-11-27 11:00
Peer-Review Started	2014-11-27 19:50
To Make the First Decision	2014-12-26 13:17
Return for Revision	2015-01-01 16:53
Revised	2015-01-09 01:49
Second Decision	2015-03-16 17:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-04-02 16:21
Articles in Press	2015-04-02 16:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-04-22 16:08
Publish the Manuscript Online	2015-05-21 14:15

ISSN	2220-315x (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Anesthesiology
Manuscript Type	Review
Article Title	Are there new approaches for diagnosis, therapy guidance and outcome prediction of sepsis?
Manuscript Source	Invited Manuscript
All Author List	Dubravka Kojic, Benedikt H Siegler, Florian Uhle, Christoph Lichtenstern, Peter P Nawroth, Markus A Weigand, Stefan Hofer and Thorsten Brenner
Funding Agency and Grant Number
Corresponding Author	Dr. Dubravka Kojic, Department of Anesthesiology, Heidelberg University Hospital, Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany. dubravka.kojic@med.uni-heidelberg.de
Key Words	Clinical decision-making; Biomarkers; Early prediction; Sepsis and mortality
Core Tip	Sepsis is a complex continuum of disturbed systems. Despite the presence of clinical consensus criteria, the early diagnosis especially in the perioperative setting is challenging. A magnitude of potential new biomarkers is tested for this purpose, but evidence is mounting that due to the complex nature of the syndrome, biomarkers are rather complementary tools for clinical decision making than “magic bullets”. Moreover, biomarkers are also evaluated for therapy guidance, linking diagnostic results to an individual therapeutic regime. This review summarizes the developments in the biomarker field, aiming to provide an overview about current targets and their limitations.
Publish Date	2015-05-21 14:15
Citation	Kojic D, Siegler BH, Uhle F, Lichtenstern C, Nawroth PP, Weigand MA, Hofer S, Brenner T. Are there new approaches for diagnosis, therapy guidance and outcome prediction of sepsis? World J Exp Med 2015; 5(2): 50-63
URL	http://www.wjgnet.com/2220-315X/full/v5/i2/50.htm
DOI	http://dx.doi.org/10.5493/wjem.v5.i2.50

Full Article (PDF)	WJEM-5-50.pdf
Full Article (Word)	WJEM-5-50.doc
Manuscript File	15457-Review.docx
Answering Reviewers	15457-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	15457-Conflict-of-interest statement.pdf
Copyright License Agreement	15457-Copyright assignment.pdf
Peer-review Report	15457-Peer-review(s).pdf
Scientific Misconduct Check	15457-Scientific misconduct check.pdf
Scientific Editor Work List	15457-Scientific editor work list.pdf