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7/8/2015 12:00:00 PM | Browse: 500 | Download: 1101
Publication Name World Journal of Gastroenterology
Manuscript ID 16233
Country/Territory China
Received
2015-01-06 09:45
Peer-Review Started
2015-01-06 16:09
To Make the First Decision
2015-01-22 16:41
Return for Revision
2015-02-02 08:05
Revised
2015-02-14 10:23
Second Decision
2015-03-25 16:56
Accepted by Journal Editor-in-Chief
2015-03-26 07:13
Accepted by Company Editor-in-Chief
2015-03-31 09:56
Articles in Press
2015-03-31 11:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-04-30 18:59
Typeset the Manuscript
2015-06-23 11:40
Publish the Manuscript Online
2015-07-08 12:01
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Endocrinology and Metabolism
Manuscript Type Basic Study
Article Title Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats
Manuscript Source Unsolicited Manuscript
All Author List Shu-Jun Jiang, Hui Dong, Jing-Bin Li, Li-Jun Xu, Xin Zou, Kai-Fu Wang, Fu-Er Lu and Ping Yi
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 30973836
Corresponding author Ping Yi, PhD, Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, Hubei Province, China. pyi219@163.com
Keywords Berberine; Diabetes; AMPK; Hepatic gluconeogenesis; LKB1; TORC2
Core Tip We showed that liver kinase (LK)B1 acts as the upstream regulator of AMP-activated protein kinase (AMPK) and participates in gluconeogenesis. AMPK phosphorylation triggers CREB-regulated transcription co-activator (TORC)2 phosphorylation, which results in the inhibition of the nuclear translocation of TORC2. Thus, gluconeogenesis is restrained. No previous studies have reported the molecular mechanisms of berberine reducing hyperglycemia via the inhibition of hepatic gluconeogenesis. We found that berberine upregulated protein expression of LKB1, AMPK, p-AMPK and p-TORC2. Moreover, we observed that berberine inhibited the translocation of TOCR2 into the cell nucleus.
Publish Date 2015-07-08 12:01
Citation Jiang SJ, Dong H, Li JB, Xu LJ, Zou X, Wang KF, Lu FE, Yi P. Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats. World J Gastroenterol 2015; 21(25): 7777-7785
Url http://www.wjgnet.com/1007-9327/full/v21/i25/7777.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i25.7777
Full Article (PDF) WJG-21-7777.pdf
Full Article (Word) WJG-21-7777.doc
Manuscript File 16233-Review.docx
Answering Reviewers 16233-Answering reviewers.pdf
Audio Core Tip 16233-Audio core tip.mp3
Biostatistics Review Certificate 16233-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 16233-Conflict-of-interest statement.pdf
Copyright License Agreement 16233-Copyright assignment.pdf
Data Sharing Statement 16233-Data sharing statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 16233-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 16233-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 16233-Language certificate.pdf
Peer-review Report 16233-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 16233-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 16233-Scientific misconduct check.pdf
Scientific Editor Work List 16233-Scientific editor work list.pdf