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6/29/2015 4:40:00 PM | Browse: 777 | Download: 1060
Publication Name World Journal of Gastroenterology
Manuscript ID 16371
Country/Territory Italy
2015-01-14 08:28
Peer-Review Started
2015-01-14 14:38
To Make the First Decision
2015-03-26 18:20
Return for Revision
2015-03-27 10:38
2015-04-10 14:12
Second Decision
2015-05-13 07:32
Accepted by Journal Editor-in-Chief
2015-05-13 23:20
Accepted by Company Editor-in-Chief
2015-05-21 17:22
Articles in Press
2015-05-21 17:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-06-15 15:19
Publish the Manuscript Online
2015-06-29 16:33
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Hepatitis C treatment in the elderly: New possibilities and controversies towards interferon-free regimens
Manuscript Source Invited Manuscript
All Author List Umberto Vespasiani-Gentilucci, Giovanni Galati, Paolo Gallo, Antonio De Vincentis, Elisabetta Riva and Antonio Picardi
Funding Agency and Grant Number
Corresponding Author Umberto Vespasiani-Gentilucci, MD, PhD, Internal Medicine and Hepatology Unit, University Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Rome, Italy. u.vespasiani@unicampus.it
Key Words Hepatitis C virus; Elderly; Interferon; Ribavirin; Telaprevir; Boceprevir; Sofosbuvir; Simeprevir; Daclatasvir; Side effects; Drug-drug interactions
Core Tip Hepatitis C virus (HCV) infection is a significant threat to the health of elderly patients, in whom liver disease progresses very rapidly and extrahepatic complications affect the quality of life. Till now, treatment attempts have been substantially limited by the side effects of interferon (IFN). Here we discuss how the availability of IFN-free regimens should prompt us to change our mind when assessing treatment indication and to consider a significantly larger number of possible candidates among elderly patients. Drug-drug interactions and assessment of liver disease-dependent vs comorbidities-dependent life expectancy, rather than anagraphic age, are likely to guide the choice of the aged HCV patients to be treated in the next future.
Publish Date 2015-06-29 16:33
Citation Vespasiani-Gentilucci U, Galati G, Gallo P, De Vincentis A, Riva E, Picardi A. Hepatitis C treatment in the elderly: New possibilities and controversies towards interferon-free regimens. World J Gastroenterol 2015; 21(24): 7412-7426
URL http://www.wjgnet.com/1007-9327/full/v21/i24/7412.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i24.7412
Full Article (PDF) WJG-21-7412.pdf
Full Article (Word) WJG-21-7412.doc
Manuscript File 16371-Review.docx
Answering Reviewers 16371-Answering reviewers.pdf
Audio Core Tip 16371-Audio core tip.wav
Conflict-of-Interest Disclosure Form 16371-Conflict-of-interest statement.pdf
Copyright License Agreement 16371-Copyright assignment.pdf
Peer-review Report 16371-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 16371-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 16371-Scientific misconduct check.pdf
Scientific Editor Work List 16371-Scientific editor work list.pdf