Publication Name	World Journal of Gastroenterology
Manuscript ID	17556
Country	China

Received	2015-03-12 18:06
Peer-Review Started	2015-03-13 13:37
To Make the First Decision	2015-06-02 15:31
Return for Revision	2015-06-07 17:53
Revised	2015-06-19 20:46
Second Decision	2015-07-27 20:13
Accepted by Journal Editor-in-Chief	2015-07-27 21:29
Accepted by Company Editor-in-Chief	2015-08-25 18:12
Articles in Press	2015-08-25 18:12
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-09-25 07:32
Typeset the Manuscript	2015-10-27 09:34
Publish the Manuscript Online	2015-11-18 12:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Retinoic acid receptor α promotes autophagy to alleviate liver ischemia and reperfusion injury
Manuscript Source	Unsolicited Manuscript
All Author List	Chen Zhong, Li-Yong Pu, Ming-Ming Fang, Zhen Gu, Jian-Hua Rao and Xue-Hao Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81273261
Corresponding Author	Xue-Hao Wang, MD, PhD, Key Labo­ratory of Living Donor Liver Transplantation of Chinese Ministry of Health, Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. wangxh@njmu.edu.cn
Key Words	Ischemia/reperfusion; Retinoic acid rece­ptor α; Foxo3a; Foxo1; Autophagy
Core Tip	To investigate the role of autophagy and the relationship between all-trans retinoic acid (ATRA) and autophagy in liver ischemia and reperfusion (IR) injury. We found that ATRA pretreatment alleviated liver IR injury by inducing autophagy and it may involves retinoic acid receptor α (RARα) activity. To clarify the mechanism of RARα, we used LE540 to inhibit RARα during reactive oxygen species-inducing cell damage in vitro. Our data showed that RARα activation enhanced Foxo3a and p-Akt expression except Foxo1. The Foxo3a/p-Akt/Foxo1 pathway has previously been proven to promote autophagy. Hence, we conclude that ATRA activates RARα to reduce liver IR injury by regulating the Foxo3a/p-Akt/Foxo1 pathway to promote autophagy.
Publish Date	2015-11-18 12:39
Citation	Zhong C, Pu LY, Fang MM, Gu Z, Rao JH, Wang XH. Retinoic acid receptor α promotes autophagy to alleviate liver ischemia and reperfusion injury. World J Gastroenterol 2015; 21(43): 12381-12391
URL	http://www.wjgnet.com/1007-9327/full/v21/i43/12381.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i43.12381

Full Article (PDF)	WJG-21-12381.pdf
Full Article (Word)	WJG-21-12381.doc
Manuscript File	17556-Review.docx
Answering Reviewers	17556-Answering reviewers.pdf
Audio Core Tip	17556-Audio core tip.mp3
Biostatistics Review Certificate	17556-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	17556-Conflict-of-interest statement.pdf
Copyright License Agreement	17556-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20150312103601.pdf
Institutional Animal Care and Use Committee Approval Form or Document	17556-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	17556-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	17556-Language certificate.pdf
Peer-review Report	17556-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	17556-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	17556-Scientific misconduct check.pdf
Scientific Editor Work List	17556-Scientific editor work list.pdf