Publication Name	World Journal of Gastroenterology
Manuscript ID	17601
Country	Taiwan

Received	2015-03-16 09:15
Peer-Review Started	2015-03-16 15:01
To Make the First Decision	2015-05-18 12:07
Return for Revision	2015-05-20 10:55
Revised	2015-06-01 20:54
Second Decision	2015-07-03 20:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-07-08 17:20
Articles in Press	2015-07-08 17:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-08-13 10:10
Publish the Manuscript Online	2015-08-28 17:04

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Distinctive roles of unsaturated and saturated fatty acids in hyperlipidemic pancreatitis
Manuscript Source	Unsolicited Manuscript
All Author List	Yu-Ting Chang, Ming-Chu Chang, Chien-Chih Tung, Shu-Chen Wei and Jau-Min Wong
Funding Agency and Grant Number
Corresponding Author	Yu-Ting Chang, MD, MS, PhD, Department of Internal Medicine, National Taiwan University Hospital, No. 7 Chung Shan South Road, Taipei, Taiwan. yutingchang@ntu.edu.tw
Key Words	Unsaturated fatty acid; Saturated fatty acid; Hypertriglyceridemia; Acute pancreatitis; Calcium
Core Tip	The mechanism by which severe hypertriglyceridemia precipitates acute pancreatitis remains unknown. Abnormal sustained elevated cytosolic Ca2+ signals, which cause abnormal intracellular enzyme activation, are crucial in the initiation of acute pancreatitis. Unsaturated fatty acids at high concentrations induced a persistent rise in cytosolic Ca2+ concentrations in acinar cells and caused intra-acinar cell trypsin activation and cell damage. Unsaturated fatty acids at low concentrations and saturated fatty acids and triglycerides at low and high concentrations were unable to induce a rise in Ca2+ concentrations in acinar cells. Unsaturated fatty acids at high concentrations may play a crucial and distinctive role in the pathogenesis of hypertriglyceridemic pancreatitis.
Publish Date	2015-08-28 17:04
Citation	Chang YT, Chang MC, Tung CC, Wei SC, Wong JM. Distinctive roles of unsaturated and saturated fatty acids in hyperlipidemic pancreatitis. World J Gastroenterol 2015; 21(32): 9534-9543
URL	http://www.wjgnet.com/1007-9327/full/v21/i32/9534.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i32.9534

Full Article (PDF)	WJG-21-9534.pdf
Full Article (Word)	WJG-21-9534.doc
Manuscript File	17601-Review.docx
Answering Reviewers	17601-Answering reviewers.pdf
Audio Core Tip	17601-Audio core tip.MP3
Conflict-of-Interest Disclosure Form	17601-Conflict-of-interest statement.pdf
Copyright License Agreement	17601-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	17601-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	17601-Language certificate.pdf
Peer-review Report	17601-Peer-review(s).pdf
Scientific Misconduct Check	17601-Scientific misconduct check.pdf
Scientific Editor Work List	17601-Scientific editor work list.pdf