Publication Name	World Journal of Hepatology
Manuscript ID	17761
Country	Italy

Received	2015-03-23 08:17
Peer-Review Started	2015-03-25 19:18
To Make the First Decision	2015-05-13 19:50
Return for Revision	2015-05-18 19:43
Revised	2015-07-03 12:51
Second Decision	2016-02-15 17:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-02-24 14:17
Articles in Press	2016-02-24 14:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-02-29 16:53
Publish the Manuscript Online	2016-03-03 11:05

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Surgery
Manuscript Type	Minireviews
Article Title	Indocyanine green kinetics to assess liver function: Ready for a clinical dynamic assessment in major liver surgery?
Manuscript Source	Invited Manuscript
All Author List	Andrea De Gasperi, Ernestina Mazza and Manlio Prosperi
Funding Agency and Grant Number
Corresponding Author	Andrea De Gasperi, MD, 2° Servizio Anestesia e Rianimazione, Ospedale Niguarda Ca’ Granda, Piazza Ospedale Maggiore 3, 20162 Milano, Italy. andrea.degasperi@ospedaleniguarda.it
Key Words	Liver function tests; Indocyanine green; Hepatic clearance; Liver surgery; Liver transplantation; Intraabdominal hypertension; Portal hypertension
Core Tip	Non invasive monitors for indocyanine green (ICG) clearance (PDR and R15) are now available for a rapid assessment of liver function both in the intensive care unit and in major liver surgery. After having reviewed the basic concepts of hepatic clearance, we have analysed the most common indications of ICG kinetic parameters in clinical practice, focusing on the diagnostic and prognostic role of PDR and R15 in the perioperative period of major resective liver surgery and liver transplantation. Since ICG parameters have still some limitations, we will underline the conditions (mainly hyperbilirubinemia and severe peripheral hypoperfusion) able to alter the reliability of these tests.
Publish Date	2016-03-03 11:05
Citation	De Gasperi A, Mazza E, Prosperi M. Indocyanine green kinetics to assess liver function: Ready for a clinical dynamic assessment in major liver surgery? World J Hepatol 2016; 8(7): 355-367
URL	http://www.wjgnet.com/1948-5182/full/v8/i7/355.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i7.355

Full Article (PDF)	WJH-8-355.pdf
Full Article (Word)	WJH-8-355.doc
Manuscript File	17761-Review.docx
Answering Reviewers	17761-Answering reviewers.pdf
Audio Core Tip	17761-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	17761-Conflict-of-interest statement.pdf
Copyright License Agreement	17761-Copyright assignment.pdf
Peer-review Report	17761-Peer-review(s).pdf
Scientific Misconduct Check	17761-Scientific misconduct check.pdf
Scientific Editor Work List	17761-Scientific editor work list.pdf