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9/23/2015 12:28:00 PM | Browse: 1096 | Download: 1200
Publication Name World Journal of Hepatology
Manuscript ID 18457
Country Japan
2015-04-21 08:43
Peer-Review Started
2015-04-22 08:54
To Make the First Decision
2015-07-17 17:53
Return for Revision
2015-07-25 15:45
2015-07-27 20:13
Second Decision
2015-09-02 15:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-09-08 15:59
Articles in Press
2015-09-08 15:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-09-14 09:15
Publish the Manuscript Online
2015-09-23 12:28
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Minireviews
Article Title Hepatitis B virus reactivation with a rituximab-containing regimen
Manuscript Source Invited Manuscript
All Author List Yutaka Tsutsumi, Yoshiya Yamamoto, Shinichi Ito, Hiroyuki Ohigashi, Souichi Shiratori, Hirohito Naruse and Takanori Teshima
Funding Agency and Grant Number
Corresponding Author Yutaka Tsutsumi, MD, PhD, Department of Hematology, Hakodate Municipal Hospital, 1-10-1, Minato-cho, Hakodate 041-8680, Japan. yutsutsu@shore.ocn.ne.jp
Key Words Rituximab; Hepatitis B virus; Reactivation; Nucleoside analog; Non-Hodgkin’s lymphoma
Core Tip For preventive measures against hepatitis B virus (HBV) reactivation during rituximab treatment, hepatitis B surface (HBs) antigen positive and HBc antibody positive/HBs antibody negative patients are subject to prophylactic treatment with nucleoside analogs. During rituximab treatment, the HBV-DNA levels of patients who are HBc antibody positive (HBs antibody positive or negative) are ideally monitored with PCR once a month. If the PCR results are positive, the administration of nucleoside analogs is initiated. However, since monitoring HBV-DNA levels is expensive, it might be preferable to follow the HBs antibodies instead. Due to wide differences in the insurance situa-tions in each country, including the follow-up intervals, further research must determine ideal follow-up intervals. However, no standard exists for the timing of this treatment’s termination. For HBs antigen negative patients who also receive nucleoside analog treatment, it will be necessary in the future to evaluate the possibility of switching to a vaccine when a patient becomes HBs antibody positive.
Publish Date 2015-09-23 12:28
Citation Tsutsumi Y, Yamamoto Y, Ito S, Ohigashi H, Shiratori S, Naruse H, Teshima T. Hepatitis B virus reactivation with a rituximab-containing regimen. World J Hepatol 2015; 7(21): 2344-2351
URL http://www.wjgnet.com/1948-5182/full/v7/i21/2344.htm
DOI http://dx.doi.org/10.4254/wjh.v7.i21.2344
Full Article (PDF) WJH-7-2344.pdf
Full Article (Word) WJH-7-2344.doc
Manuscript File 18457-Review.docx
Answering Reviewers 18457-Answering reviewers.pdf
Audio Core Tip 18457-Audio core tip.wav
Conflict-of-Interest Disclosure Form 18457-Conflict-of-interest statement.pdf
Copyright License Agreement 18457-Copyright assignment.pdf
Peer-review Report 18457-Peer-review(s).pdf
Scientific Misconduct Check 18457-Scientific misconduct check.pdf
Scientific Editor Work List 18457-Scientific editor work list.pdf