| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Magnesium isoglycyrrhizinate inhibits inflammatory response through STAT3 pathway to protect remnant liver function
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Guang-Hua Tang, Hua-Yu Yang, Jin-Chun Zhang, Jin-Jun Ren, Xin-Ting Sang, Xin Lu, Shou-Xian Zhong and Yi-Lei Mao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| State Science and Technology Ministry |
2012BAI06B01 |
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| Corresponding Author |
Yi-Lei Mao, MD, PhD, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and PUMC, No. 1 Shuaifuyuan, Wangfujing, Beijing 100730, China. yileimao@126.com
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| Key Words |
Magnesium isoglycyrrhizinate; Excessive liver resection; Inflammation; Liver regeneration; STAT3 |
| Core Tip |
Magnesium isoglycyrrhizinate (MgIG), a hepatocyte protective agent, has been shown to have the effects of anti-inflammation, liver cell membrane protection, and liver function improvement. We designed this study, by using the standard 90% hepatectomy model in rats, to clarify the liver protecting function of MgIG and its mechanism. We have researched pos-toperative survival time, hepatocyte regeneration, liver function, serum inflammatory cytokines, STAT3 protein and mRNA expression. The protective effect of MgIG in standard 90% hepatectomy is limited, which can prolong the survival time. This hepatoprotective effect was not mediated by increasing hepatocyte regeneration but rather by inhibiting the inflammatory response through inhibition of the STAT3 pathway. |
| Publish Date |
2015-11-18 12:39 |
| Citation |
Tang GH, Yang HY, Zhang JC, Ren JJ, Sang XT, Lu X, Zhong SX, Mao YL. Magnesium isoglycyrrhizinate inhibits inflammatory response through STAT3 pathway to protect remnant liver function. World J Gastroenterol 2015; 21(43): 12370-12380 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i43/12370.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i43.12370 |
