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11/3/2015 5:30:00 PM | Browse: 631 | Download: 801
Publication Name World Journal of Gastroenterology
Manuscript ID 19447
Country/Territory Japan
Received
2015-05-08 15:04
Peer-Review Started
2015-05-11 21:21
To Make the First Decision
2015-07-13 15:18
Return for Revision
2015-07-17 16:51
Revised
2015-08-08 00:00
Second Decision
2015-09-13 22:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-09-15 13:43
Articles in Press
2015-09-15 13:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-10-16 15:31
Publish the Manuscript Online
2015-11-03 17:31
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Topic Highlights
Article Title Do vasopressin V2 receptor antagonists benefit cirrhotics with refractory ascites?
Manuscript Source Invited Manuscript
All Author List Hiroshi Fukui
Funding Agency and Grant Number
Corresponding Author Hiroshi Fukui, MD, PhD, Professor emeritus, Department of Gastroenterology, Endocrinology and Metabolism, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan. hfukui@naramed-u.ac.jp
Key Words Liver cirrhosis; Ascites; Hyponatremia; Pathophysiology; V2 receptor antagonist
Core Tip Dilutional hyponatremia is a frequent complication with high morbidity and mortality in advanced liver cirrhosis with ascites. It is attributable to disturbed water excretion related to enhanced vasopressin activity on the background of underfilling state in the splanchnic arterial circulation. V2 receptor antagonist is theoretically promising for the future treatment of hyponatremia and ascites. The present review aimed to summarize the pathophysiological backgrounds of ascites and hyponatremia and to introduce major results of all controlled trials. Although there existed several unsolved problems and controversies on the topic, discussions from the basic standpoints may light up the dark road.
Publish Date 2015-11-03 17:31
Citation Fukui H. Do vasopressin V2 receptor antagonists benefit cirrhotics with refractory ascites? World J Gastroenterol 2015; 21(41): 11584-11596
Url http://www.wjgnet.com/1007-9327/full/v21/i41/11584.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i41.11584
Full Article (PDF) WJG-21-11584.pdf
Full Article (Word) WJG-21-11584.doc
Manuscript File 19447-Review.docx
Answering Reviewers 19447-Answering reviewers.pdf
Audio Core Tip 19447-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 19447-Conflict-of-interest statement.pdf
Copyright License Agreement 19447-Copyright assignment.pdf
Peer-review Report 19447-Peer-review(s).pdf
Scientific Misconduct Check 19447-Scientific misconduct check.pdf
Scientific Editor Work List 19447-Scientific editor work list.pdf