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8/20/2015 1:37:00 PM | Browse: 944 | Download: 883
Publication Name World Journal of Gastroenterology
Manuscript ID 19472
Country/Territory United States
Received
2015-05-09 13:19
Peer-Review Started
2015-05-12 15:38
To Make the First Decision
2015-06-02 15:09
Return for Revision
2015-06-04 15:09
Revised
2015-06-13 09:35
Second Decision
2015-07-07 22:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-07-08 17:53
Articles in Press
2015-07-08 17:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-08-07 11:24
Publish the Manuscript Online
2015-08-20 13:37
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Genetics & Heredity
Manuscript Type Topic Highlights
Article Title Lynch syndrome and Lynch syndrome mimics: The growing complex landscape of hereditary colon cancer
Manuscript Source Invited Manuscript
All Author List John M Carethers and Elena M Stoffel
Funding Agency and Grant Number
Funding Agency Grant Number
United States Public Health Service DK067287
United States Public Health Service CA162147
A. Alfred Taubman Medical Research Institute of the University of Michigan
Corresponding Author John M Carethers, MD, Division of Gastroenterology, Department of Internal Medicine, University of Michigan, 500 S. State Street, Ann Arbor, MI 48109-5368, United States. jcarethe@umich.edu
Key Words Hereditary non-polyposis colorectal cancer; Lynch syndrome; Lynch-like syndrome; Familial colorectal cancer; DNA mismatch repair; microsatellite instability; Familial colorectal cancer type X; Constitutional mismatch repair deficiency syndrome; Hereditary colorectal cancer
Core Tip Clinical criteria and phenotypic presentation of patients and families with hereditary non-polyposis colorectal cancer (HNPCC) do not adequately differentiate the several genetic diseases now classified under HNPCC. Tumor analysis for microsatellite instability (MSI) can dichotimize for the clinician conditions with MSI or without MSI, allowing a focused differential diagnosis. Individual or panel germline genetic testing can further differentiate HNPCC into its genetically defined syndromes or its phenocopies.
Publish Date 2015-08-20 13:37
Citation Carethers JM, Stoffel EM. Lynch syndrome and Lynch syndrome mimics: The growing complex landscape of hereditary colon cancer. World J Gastroenterol 2015; 21(31): 9253-9261
URL http://www.wjgnet.com/1007-9327/full/v21/i31/9253.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i31.9253
Full Article (PDF) WJG-21-9253.pdf
Full Article (Word) WJG-21-9253.doc
Manuscript File 19472-Review.docx
Answering Reviewers 19472-Answering reviewers.pdf
Audio Core Tip 19472-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 19472-Conflict-of-interest statement.pdf
Copyright License Agreement 19472-Copyright assignment.pdf
Peer-review Report 19472-Peer-review(s).pdf
Scientific Misconduct Check 19472-Scientific misconduct check.pdf
Scientific Editor Work List 19472-Scientific editor work list.pdf