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12/2/2015 11:38:00 AM | Browse: 558 | Download: 737
Publication Name World Journal of Experimental Medicine
Manuscript ID 20017
Country/Territory Greece
Received
2015-05-27 20:39
Peer-Review Started
2015-05-30 11:42
To Make the First Decision
2015-07-03 16:46
Return for Revision
2015-07-10 19:06
Revised
2015-07-21 02:00
Second Decision
2015-09-02 10:31
Accepted by Journal Editor-in-Chief
2015-09-02 18:04
Accepted by Company Editor-in-Chief
2015-09-16 18:39
Articles in Press
2015-09-16 18:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-11-13 18:34
Publish the Manuscript Online
2015-11-23 08:36
ISSN 2220-315x (online)
Open Access Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry and Molecular Biology
Manuscript Type Editorial
Article Title Polycystins and mechanotransduction: From physiology to disease
Manuscript Source Invited Manuscript
All Author List Christina Piperi and Efthimia K Basdra
Funding Agency and Grant Number
Corresponding author Efthimia K Basdra, Associate Professor, Department of Biological Chemistry - Cellular and Molecular Biomechanics Unit, Medical School, University of Athens Medical School, 75, M. Asias Street, 11527 Athens, Greece. ebasdra@med.uoa.gr
Key Words Polycystins; Mechanotransduction; Kidney; Endothelium; Osteoblasts; Cancer
Core Tip Polycystins are key regulators of mechano-sensation in several cell types including kidney, vascular endothelial and smooth muscle cells, osteoblasts and cardiac myocytes. Their expression in primary cilium, plasma membrane and endoplasmic reticulum, along with their ability to interact with diverse ion channels, cell-cell and cell-extracellular matrix junctional proteins renders polycystins as essential regulators of overall cellular mechanoresponse. Abnormal expression or genetic defects of polycystins result in severe structural and mechanosensing faults including cyst formation, deregulated flow sensing, aneurysms, defective bone development and cancer progression, highlighting their crucial role in human physiology.
Publish Date 2015-11-23 08:36
Citation Piperi C, Basdra EK. Polycystins and mechanotransduction: From physiology to disease. World J Exp Med 2015; 5(4): 200-205
Url http://www.wjgnet.com/2220-315X/full/v5/i4/200.htm
DOI http://dx.doi.org/10.5493/wjem.v5.i4.200
Full Article (PDF) WJEM-5-200.pdf
Full Article (Word) WJEM-5-200.doc
Manuscript File 20017-Review.doc
Answering Reviewers 20017-Answering reviewers.pdf
Audio Core Tip 20017-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 20017-Conflict-of-interest statement.pdf
Copyright License Agreement 20017-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 20017-Language certificate.pdf
Peer-review Report 20017-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 20017-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 20017-Scientific misconduct check.pdf
Scientific Editor Work List 20017-Scientific editor work list.pdf