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9/15/2014 8:54:00 PM | Browse: 432 | Download: 339
Publication Name World Journal of Gastroenterology
Manuscript ID 2049
Country/Territory Japan
Received
2013-01-23 08:56
Peer-Review Started
2013-01-24 12:01
To Make the First Decision
2013-03-04 11:54
Return for Revision
2013-03-08 10:14
Revised
2013-03-11 23:36
Second Decision
2013-06-19 12:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-06-20 00:44
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
2013-07-22 16:23
Typeset the Manuscript
2013-07-30 16:09
Publish the Manuscript Online
2013-08-13 11:13
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Autobiography
Article Title Histopathology of type C liver disease for determining hepatocellular carcinoma risk factors
Manuscript Source Invited Manuscript
All Author List Hiroshi Matsumura, Kazushige Nirei, Hitomi Nakamura, Teruhisa Higuchi, Yasuo Arakawa, Masahiro Ogawa, Naohide Tanaka and Mitsuhiko Moriyama
Funding Agency and Grant Number
Corresponding Author Hiroshi Matsumura, MD, PhD, Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashiku, Tokyo 173-8610, Japan. hsh.matsumura@nifty.com
Key Words Hepatocellular carcinoma; Irregular regeneration of hepatocytes; Liver fibrosis; Type C chronic liver disease; Histopathology of liver biopsy
Core Tip To evaluate the histopathological findings of type C liver disease to determine risk factors for the development of hepatocellular carcinoma (HCC), we studied 232 patients, who underwent liver biopsy, with sustained virological response after interferon therapy. We investigated in detail the histopathological findings, and analyzed the findings to determine the risk factors. Consequently, atypical hepatocytes among irregular regeneration of hepatocytes may be an important risk factor for HCC development, along with progression of liver fibrosis. Clarification of atypical hepatocytes as a risk factor of carcinogenesis may aid in the early diagnosis of HCC.
Publish Date 2013-08-13 11:13
Citation Matsumura H, Nirei K, Nakamura H, Higuchi T, Arakawa Y, Ogawa M, Tanaka N, Moriyama M. Histopathology of type C liver disease for determining hepatocellular carcinoma risk factors. World J Gastroenterol 2013; 19(30): 4887-4896
Url http://www.wjgnet.com/1007-9327/full/v19/i30/4887.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i30.4887
Full Article (PDF) WJG-19-4887.pdf
Manuscript File 2049-Review.doc
Answering Reviewers 2049-Answering reviewers.pdf
Copyright License Agreement 2049-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 2049-Language certificate.docx
Peer-review Report 2049-Peer review.pdf
Scientific Editor Work List 2049-Scientific editor work list.doc