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11/24/2015 3:55:00 PM | Browse: 592 | Download: 698
Publication Name World Journal of Gastroenterology
Manuscript ID 20713
Country/Territory Japan
2015-06-17 08:20
Peer-Review Started
2015-06-19 11:03
To Make the First Decision
2015-07-19 17:15
Return for Revision
2015-07-27 11:28
2015-08-07 14:36
Second Decision
2015-09-12 22:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-09-14 11:38
Articles in Press
2015-09-14 11:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-10-28 12:12
Publish the Manuscript Online
2015-11-18 12:39
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Randomized Clinical Trial
Article Title Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects
Manuscript Source Unsolicited Manuscript
All Author List Masahiro Kikuchi, Yusuke Ushida, Hirokazu Shiozawa, Rumiko Umeda, Kota Tsuruya, Yudai Aoki, Hiroyuki Suganuma and Yasuhiro Nishizaki
Funding Agency and Grant Number
Corresponding author Yasuhiro Nishizaki, MD, PhD, Professor, Department of Clinical Health Science, Tokai University Tokyo Hospital, 1-2-5, Yoyogi, Shibuya-ku, Tokyo 153-0065, Japan. dr-yasu@jcom.home.ne.jp
Keywords Sulforaphane; Glucoraphanin; Broccoli sprout; Nrf2; Hepatic abnormality; Oxidative stress; Phase 2 enzymes
Core Tip A randomized, placebo-controlled, double blind trial was conducted to assess the efficacy of dietary supplementation with broccoli sprout extract containing glucoraphanin (GR), a sulforaphane (SF) precursor, on hepatic abnormalities in Japanese men without changing their lifestyle or habits. Suppl-ementation for 2 mo significantly decreased serum levels of liver function markers such as alanine amino-transferase and γ-glutamyl transpeptidase. The effect was associated with a reduction of urinary 8-hydro-xydeoxyguanosine, an oxidative stress marker. Dietary supplementation with SF precursor GR is effective in improving liver function, and represents a potent method for maintaining good liver condition.
Publish Date 2015-11-18 12:39
Citation Kikuchi M, Ushida Y, Shiozawa H, Umeda R, Tsuruya K, Aoki Y, Suganuma H, Nishizaki Y. Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects. World J Gastroenterol 2015; 21(43): 12457-12467
Url http://www.wjgnet.com/1007-9327/full/v21/i43/12457.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i43.12457
Full Article (PDF) WJG-21-12457.pdf
Full Article (Word) WJG-21-12457.doc
Manuscript File 20713-Review.docx
Answering Reviewers 20713-Ansewring reviewers.pdf
Audio Core Tip 20713-Audio core tip.mp3
Biostatistics Review Certificate 20713-Biostatistics statement.pdf
Clinical Trial Registration Statement 20713-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form 20713-Conflict-of-interest statement.pdf
Copyright License Agreement 20713-Copyright assignment.pdf
Data Sharing Statement 20713-Data sharing statemant.pdf
Signed Informed Consent Form(s) or Document(s) 20713-Clinical trial registration statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 20713-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 20713-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 20713-Language certificate.pdf
Peer-review Report 20713-Peer-review(s).pdf
Scientific Misconduct Check 20713-Scientific misconduct check.pdf
Scientific Editor Work List 20713-Scientific editor work list.pdf