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11/24/2015 3:55:00 PM | Browse: 580 | Download: 668
Publication Name World Journal of Gastroenterology
Manuscript ID 21087
Country/Territory Italy
Received
2015-06-30 12:02
Peer-Review Started
2015-07-03 08:28
To Make the First Decision
2015-08-31 08:54
Return for Revision
2015-08-31 16:33
Revised
2015-09-03 01:52
Second Decision
2015-10-12 09:04
Accepted by Journal Editor-in-Chief
2015-10-14 08:47
Accepted by Company Editor-in-Chief
2015-10-20 09:54
Articles in Press
2015-10-20 09:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-11-03 10:08
Publish the Manuscript Online
2015-11-18 12:39
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Effect of rifaximin on gut microbiota composition in advanced liver disease and its complications
Manuscript Source Invited Manuscript
All Author List Francesca Romana Ponziani, Viviana Gerardi, Silvia Pecere, Francesca D’Aversa, Loris Lopetuso, Maria Assunta Zocco, Maurizio Pompili and Antonio Gasbarrini
Funding Agency and Grant Number
Corresponding author Silvia Pecere, MD, Internal Medicine and Gastroenterology, Agostino Gemelli Hospital, via Moscati 31, 00168 Rome, Italy. silvia.pecere@gmail.com
Key Words Liver cirrhosis; Gut microbiota; Rifaximin; Hepatic encephalopathy; Spontaneous bacterial peritonitis; Ascites; Endotoxemia; Thrombocytopenia
Core Tip Advanced liver disease is characterized by intestinal dysbiosis, which has been involved in the pathogenesis of complications. Rifaximin is able to improve cognitive tests and practical abilities, to reduce the risk of hepatic encephalopathy (he) recurrence and the number of he-related hospitalizations. Rifaximin efficacy seems not associated with major changes in gut bacteria composition but rather with a shift in the microbiome functionality. Rifaximin is useful in the prevention of spontaneous bacterial peritonitis in patients with ascites. Rifaximin reduces endotoxemia and has beneficial effects on cirrhotic patients hemo-dynamics, reducing the incidence of complications related to portal hypertension.
Publish Date 2015-11-18 12:39
Citation Ponziani FR, Gerardi V, Pecere S, D’Aversa F, Lopetuso L, Zocco MA, Pompili M, Gasbarrini A. Effect of rifaximin on gut microbiota composition in advanced liver disease and its complications. World J Gastroenterol 2015; 21(43): 12322-12333
Url http://www.wjgnet.com/1007-9327/full/v21/i43/12322.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i43.12322
Full Article (PDF) WJG-21-12322.pdf
Full Article (Word) WJG-21-12322.doc
Manuscript File 21087-Review.docx
Answering Reviewers 21087-Answering reviewers.pdf
Audio Core Tip 21087-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 21087-Conflict of interest statement.pdf
Copyright License Agreement 21087-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 21087-Language certificate.pdf
Peer-review Report 21087-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 21087-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 21087-Scientific misconduct check.pdf
Scientific Editor Work List 21087-Scientific editor work list.pdf