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1/31/2016 4:11:00 PM | Browse: 1442 | Download: 2050
Publication Name World Journal of Gastrointestinal Pathophysiology
Manuscript ID 21479
Country/Territory Germany
Received
2015-07-15 09:27
Peer-Review Started
2015-07-17 18:05
To Make the First Decision
2015-08-31 16:38
Return for Revision
2015-09-02 15:15
Revised
Second Decision
2015-12-11 12:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-12-18 17:15
Articles in Press
2015-12-18 17:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-01-23 11:57
Publish the Manuscript Online
2016-01-31 16:11
ISSN 2150-5330 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Observational Study
Article Title Efficacy and tolerability of hydrogen carbonate-rich water for heartburn
Manuscript Source Unsolicited Manuscript
All Author List André-Michael Beer, Ralf Uebelhack and Ute Pohl
Funding Agency and Grant Number
Funding Agency Grant Number
Deutsche Heilbrunnen im Verband Deutscher Mineralbrunnen e. V., Germany
Corresponding Author Dr. Ute Pohl, Analyze and Realize GmbH, Waldseeweg 6, 13456 Berlin, Germany. upohl@a-r.com
Key Words Heartburn; Hydrogen carbonate-rich mineral water; Open clinical pilot study; Patients; Regurgitation; Gastroesophageal reflux disease symptoms; Dyspepsia; Blood pressure; Tolerability; Quality of life
Core Tip This open, single-center, single-arm clinical study investigated the efficacy and safety of mineral water with a high content of hydrogen carbonate in patients with heartburn. After 6 wk, the occurrence of heartburn was statistically significantly reduced both in the intention-to-treat (48 patients) and the per-protocol populations (42 patients). All dimensions of the Reflux Disease Questionnaire (heartburn, regurgitation, gastroesophageal reflux disease symptoms, dyspepsia) showed significant improvement at week 6. Likewise, disease-specific quality of life improved significantly, and there was a slight but significant decrease in blood pressure. The tolerability was rated good or very good by 96% of patients and investigators.
Publish Date 2016-01-31 16:11
Citation Beer AM, Uebelhack R, Pohl U. Efficacy and tolerability of hydrogen carbonate-rich water for heartburn. World J Gastrointest Pathophysiol 2016; 7(1): 171-180
URL http://www.wjgnet.com/2150-5330/full/v7/i1/171.htm
DOI http://dx.doi.org/10.4291/wjgp.v7.i1.171
Full Article (PDF) WJGP-7-171.pdf
Full Article (Word) WJGP-7-171.doc
Manuscript File 21479-Review.docx
Answering Reviewers 21479-Answering reviewers.pdf
Audio Core Tip 21479-Audio core tip.mp3
Biostatistics Review Certificate 21479-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 21479-Conflict-of-interest statement.pdf
Copyright License Agreement 21479-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20150714205605.pdf
Institutional Review Board Approval Form or Document 21479-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 21479-Language certificate.pdf
Peer-review Report 21479-Peer-review(s).pdf
Scientific Misconduct Check 21479-Scientific misconduct check.pdf
Scientific Editor Work List 21479-Scientific editor work list.pdf