Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	21849
Country	Italy

Received	2015-08-22 17:18
Peer-Review Started	2015-08-24 15:01
To Make the First Decision	2015-10-08 16:07
Return for Revision	2015-10-13 15:23
Revised	2015-11-16 20:55
Second Decision	2015-11-27 16:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-12-08 15:29
Articles in Press	2015-12-08 15:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-21 16:26
Publish the Manuscript Online	2016-01-31 16:11

ISSN	2150-5330 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Mucosal healing in inflammatory bowel disease: Maintain or de-escalate therapy
Manuscript Source	Invited Manuscript
All Author List	Marcello Cintolo, Giuseppe Costantino, Socrate Pallio and Walter Fries
Funding Agency and Grant Number
Corresponding Author	Walter Fries, MD, Clinical Unit for Chronic Bowel Disorders, Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, 1, 98125 Messina, Italy. fwalter@unime.it
Key Words	De-escalation; Mucosal healing; Biological therapy; Deep remission; Discontinuation; Ulcerative colitis; Crohn’s disease; Immunosuppressors
Core Tip	Mucosal healing is achieved in a discrete number of patients with immunomodulators, biologics or combined therapies. Attempts to de-escalate therapy, thus permitting a drug holiday, are disappointing. Clinical predictors to identify patients at risk for early relapse after drug withdrawal are still insufficient. Further investigations are needed to prospectively evaluate the validity of histologic healing and to validate an appropriate scoring system for histology in ulcerative colitis and in Crohn’s disease.
Publish Date	2016-01-31 16:11
Citation	Cintolo M, Costantino G, Pallio S, Fries W. Mucosal healing in inflammatory bowel disease: Maintain or de-escalate therapy. World J Gastrointest Pathophysiol 2016; 7(1): 1-16
URL	http://www.wjgnet.com/2150-5330/full/v7/i1/1.htm
DOI	http://dx.doi.org/10.4291/wjgp.v7.i1.1

Full Article (PDF)	WJGP-7-1.pdf
Full Article (Word)	WJGP-7-1.doc
Manuscript File	21849-Review.docx
Answering Reviewers	21849-Answering reviewers.pdf
Audio Core Tip	21849-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21849-Conflict-of-interest statement.pdf
Copyright License Agreement	21849-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	21849-Language certificate.pdf
Peer-review Report	21849-Peer-review(s).pdf
Scientific Misconduct Check	21849-Scientific misconduct check.pdf
Scientific Editor Work List	21849-Scientific editor work list.pdf