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11/11/2015 1:33:00 PM | Browse: 624 | Download: 684
Publication Name World Journal of Gastroenterology
Manuscript ID 22102
Country/Territory China
Received
2015-08-12 13:52
Peer-Review Started
2015-08-13 08:26
To Make the First Decision
2015-09-11 09:22
Return for Revision
2015-09-15 10:37
Revised
2015-09-18 11:31
Second Decision
2015-09-28 16:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-09-30 10:05
Articles in Press
2015-09-30 10:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-10-27 14:11
Publish the Manuscript Online
2015-11-11 13:34
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma
Manuscript Source Invited Manuscript
All Author List Amy P Chiu, Barbara R Tschida, Lilian H Lo, Branden S Moriarity, Dewi K Rowlands, David A Largaespada and Vincent W Keng
Funding Agency and Grant Number
Funding Agency Grant Number
Health Medical Research Fund 11122171
Food and Health Bureau
Hong Kong SAR Government
Department of Applied Biology and Chemical Technology
Hong Kong Polytechnic University
Hong Kong SAR 1-ZVAG
Hong Kong SAR G-YBAY
Hong Kong SAR G-UA94
Hong Kong SAR 1-ZE19
NIH IMVTP grant T32 AI083196-04( to Tschida BR)
Corresponding Author Vincent W Keng, PhD, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China. vincent.keng@polyu.edu.hk
Key Words Hepatocellular carcinoma; Hepatitis B virus; Transposable elements; Sleeping Beauty; Forward and reverse genetic screens
Core Tip Hepatocellular carcinoma (HCC) is the major type of primary liver cancer and the risk factors that contribute to its formation are hepatitis viral infection, alcohol consumption, aflatoxin exposure, hemochromatosis, and tyrosinemia. In vivo forward and reverse genetic transposon models have been used to study the genetic mechanisms of HCC, including hepatitis B viral-induced HCC. These animal models provide valuable genetic information and are important contributors to uncovering the factors involved in liver malignant transformation, invasion and metastasis. They could also be used to test potential therapeutic agents before proceeding to clinical trials in humans.
Publish Date 2015-11-11 13:34
Citation Chiu AP, Tschida BR, Lo LH, Moriarity BS, Rowlands DK, Largaespada DA, Keng VW. Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma. World J Gastroenterol 2015; 21(42): 12157-12170
Url http://www.wjgnet.com/1007-9327/full/v21/i42/12157.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i42.12157
Full Article (PDF) WJG-21-12157.pdf
Full Article (Word) WJG-21-12157.doc
Manuscript File 22102-Review.docx
Answering Reviewers 22102-Answering reviewers.pdf
Audio Core Tip 22102-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 22102-Conflict-of-interest statement.pdf
Copyright License Agreement 22102-Copyright assignment.pdf
Peer-review Report 22102-Peer-review(s).pdf
Scientific Misconduct Check 22102-Scientific misconduct check.pdf
Scientific Editor Work List 22102-Scientific editor work list.pdf