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5/17/2016 11:46:00 AM | Browse: 373 | Download: 463
Publication Name World Journal of Experimental Medicine
Manuscript ID 22384
Country/Territory Germany
Received
2015-08-28 09:52
Peer-Review Started
2015-08-31 17:13
To Make the First Decision
2015-10-27 11:22
Return for Revision
2015-11-04 20:56
Revised
2015-11-13 20:29
Second Decision
2016-02-22 11:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-03-18 16:27
Articles in Press
2016-03-18 16:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-04-26 17:53
Publish the Manuscript Online
2016-05-17 10:07
ISSN 2220-315x (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry and Molecular Biology
Manuscript Type Review
Article Title MicroRNA-regulated viral vectors for gene therapy
Manuscript Source Invited Manuscript
All Author List Anja Geisler and Henry Fechner
Funding Agency and Grant Number
Funding Agency Grant Number
Deutsche Forschungsgemeinschaft FE785/2-2
Deutsche Forschungsgemeinschaft FE785/4-1
Bundesministerium für Bildung und Entwicklung 031A331
Corresponding author Henry Fechner, DVM, Department of Applied Biochemistry, Institute of Biotechnology, Technische Universität Berlin, Gustav-Meyer-Allee 25, 13355 Berlin, Germany. henry.fechner@tu-berlin.de
Keywords MicroRNA; MicroRNA regulation; MicroRNA target sites; Viral vectors; Adeno-associated virus; RNA interference; Gene therapy; Vector targeting
Core Tip Post-transcriptional microRNA-induced suppres-sion of gene expression is a simple new, highly efficient technology to restrict transgene expression to a specific tissue. It is based on the insertion of a target sequence for a cell-specifically expressed microRNA, typically into the 3’ untranslated region of a transgene expression cassette. MicroRNA-induced regulation can result in an up to 100-fold reduction of transgene expression in tissues where expression is not desired. This targeting strategy can be used in combination with other targeting strategies to further improve vector specificity for gene therapeutic approaches.
Publish Date 2016-05-17 10:07
Citation Geisler A, Fechner H. MicroRNA-regulated viral vectors for gene therapy. World J Exp Med 2016; 6(2): 37-54
Url http://www.wjgnet.com/2220-315X/full/v6/i2/37.htm
DOI http://dx.doi.org/10.5493/wjem.v6.i2.37
Full Article (PDF) WJEM-6-37.pdf
Full Article (Word) WJEM-6-37.doc
Manuscript File 22384-Review.doc
Answering Reviewers 22384-Answering reviewers.pdf
Audio Core Tip 22384-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 22384-Conflict-of-interest statement.pdf
Copyright License Agreement 22384-Copyright assigment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 22384-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 22384-Language certificate.pdf
Peer-review Report 22384-Peer-review(s).pdf
Scientific Misconduct Check 22384-Scientific misconduct check.pdf
Scientific Editor Work List 22384-Scientific editor work list.pdf