Publication Name	World Journal of Orthopedics
Manuscript ID	22406
Country	Ireland

Received	2015-08-28 08:55
Peer-Review Started
To Make the First Decision
Return for Revision
Revised	2015-09-08 18:35
Second Decision	2015-10-22 15:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-11-04 17:22
Articles in Press	2015-11-04 17:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-10 18:09
Publish the Manuscript Online	2016-01-15 09:08

ISSN	2218-5836 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Orthopedics
Manuscript Type	Review
Article Title	Mechanical and cellular processes driving cervical myelopathy
Manuscript Source	Invited Manuscript
All Author List	Roisin T Dolan, Joseph S Butler, John M O’Byrne and Ashley R Poynton
Funding Agency and Grant Number
Corresponding Author	Dr. Roisin T Dolan, MA, MD, MRCSI, Department of Trauma and Orthopaedic Surgery, Waterford Regional Hospital, Dunmore Rd., X91 ER8E Waterford, Ireland. roshdolan@hotmail.com
Key Words	Cervical myelopathy; Cervical spine; Neck pain
Core Tip	The pathophysiology of cervical myelopathy involves a combination of mechanical static and dynamic factors, triggering a cascade of biomolecular changes to include ischemia, excitotoxicity, neuroinflammation and apoptosis. Development of targeted neuro-protective treatment strategies, specifically modulating these molecular pathways, may optimize neurological recovery following surgical decompression. The aim of this review is to provide an overview of the pathophysiological processes at play in the development of cervical myelo-pathy.
Publish Date	2016-01-15 09:08
Citation	Dolan RT, Butler JS, O’Byrne JM, Poynton AR. Mechanical and cellular processes driving cervical myelopathy. World J Orthop 2016; 7(1): 20-29
URL	http://www.wjgnet.com/2218-5836/full/v7/i1/20.htm
DOI	http://dx.doi.org/10.5312/wjo.v7.i1.20

Full Article (PDF)	WJO-7-20.pdf
Full Article (Word)	WJO-7-20.doc
Manuscript File	22406-Review.doc
Answering Reviewers	22406-Answering reviewers.pdf
Audio Core Tip	22406-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	22406-Conflict-of-interest statement.pdf
Copyright License Agreement	22406-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20150828032754.docx
Institutional Review Board Approval Form or Document	Institutional_Review_Board_Statement_20150828032525.docx
Peer-review Report	22406-Peer-review(s).pdf
Scientific Misconduct Check	22406-Scientific misconduct check.pdf
Scientific Editor Work List	22406-Scientific editor work list.pdf