Publication Name	World Journal of Methodology
Manuscript ID	22462
Country	United States

Received	2015-08-29 16:30
Peer-Review Started	2015-09-07 10:06
To Make the First Decision	2015-10-08 16:18
Return for Revision	2015-10-19 00:39
Revised	2015-11-11 00:50
Second Decision	2016-01-14 17:51
Accepted by Journal Editor-in-Chief	2016-01-15 01:52
Accepted by Executive Editor-in-Chief	2016-03-09 12:33
Articles in Press	2016-03-09 12:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-14 09:24
Publish the Manuscript Online	2016-03-18 09:50

ISSN	2222-0682 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Review
Article Title	Oncogenic role of leptin and Notch interleukin-1 leptin crosstalk outcome in cancer
Manuscript Source	Invited Manuscript
All Author List	Crystal C Lipsey, Adriana Harbuzariu, Danielle Daley-Brown and Ruben R Gonzalez-Perez
Funding Agency and Grant Number	Funding Agency Grant Number The National Cancer Institute at the National Institutes of Health 1R41 CA183399-01A1 The National Cancer Institute at the National Institutes of Health 5U54 CA118638 Congressionally Directed Medical Research Programs-Department of Defense W81XWH-13-1-0382 (to Gonzalez-Perez RR) NCI S21 MD000101 NCI 5G12 MD0076021 NCI G12 RR026250-03 NIH 1C06 RR18386 (to Morehouse School of Medicine) NIH 1C06 RR18386 (to Morehouse School of Medicine) NIH 5T32HL103104-04 (to Daley-Brown D)
Corresponding Author	Ruben R Gonzalez-Perez, PhD, Depart­ment of Microbiology, Biochemistry and Immunology, Graduate Education in Biomedical Sciences, Morehouse School of Medicine, 720 Westview Drive, Hugh Gloster Suite 329, Atlanta, GA 30310, United States. rgonzalez@msm.edu
Key Words	Obesity; Leptin; Breast cancer; Endometrial cancer; Pancreatic cancer; Notch; interleukin-1 and leptin crosstalk outcome
Core Tip	Obesity is a global pandemic and a risk factor for a number of cancers. Obesity is characterized by high levels of body fat (adiposity) and leptin. Research shows that leptin and its oncogenic crosstalk Notch, interleukin-1 and leptin crosstalk outcome (NILCO) provide insight on the link between obesity and cancer progression. Thus, leptin and NILCO can act as mito-genic, inflammatory, and angiogenic cues promoting the progression of cancer, cancer stem cells, and drug resistance. This review shows updated information on leptin and NILCO’s oncogenic roles in breast, endometrial, and pancreatic cancers.
Publish Date	2016-03-18 09:50
Citation	Lipsey CC, Harbuzariu A, Daley-Brown D, Gonzalez-Perez RR. Oncogenic role of leptin and Notch interleukin-1 leptin crosstalk outcome in cancer. World J Methodol 2016; 6(1): 43-55
URL	http://www.wjgnet.com/2222-0682/full/v6/i1/43.htm
DOI	http://dx.doi.org/10.5662/wjm.v6.i1.43

Full Article (PDF)	WJM-6-43.pdf
Full Article (Word)	WJM-6-43.doc
Manuscript File	22462-Review.docx
Answering Reviewers	22462-Answering reviewers.pdf
Audio Core Tip	22462-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	22462-Conflict-of-interest statement.pdf
Copyright License Agreement	22462-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	22462-Grant application form(s).pdf
Peer-review Report	22462-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	22462-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	22462-Scientific misconduct check.pdf
Scientific Editor Work List	22462-Scientific editor work list.pdf