Publication Name	World Journal of Critical Care Medicine
Manuscript ID	23523
Country	Greece

Received	2015-11-28 16:37
Peer-Review Started	2015-11-30 13:38
To Make the First Decision	2015-12-28 12:13
Return for Revision	2015-12-28 16:44
Revised
Second Decision	2016-02-18 11:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-03-09 12:48
Articles in Press	2016-03-09 12:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-04-11 08:55
Publish the Manuscript Online	2016-04-25 21:07

ISSN	2220-3141(online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Critical Care Medicine
Manuscript Type	Review
Article Title	Efficacy of prone position in acute respiratory distress syndrome patients: A pathophysiology-based review
Manuscript Source	Invited Manuscript
All Author List	Vasilios Koulouras, Georgios Papathanakos, Athanasios Papathanasiou and Georgios Nakos
Funding Agency and Grant Number
Corresponding Author	Vasilios Koulouras, Associate Professor in Intensive Care Medicine, Intensive Care Unit, University Hospital of Ioannina, Stavros Niarchos Avenue, 45500 Ioannina, Greece. vpkoulouras@yahoo.gr
Key Words	Prone position; Acute respiratory distress syndrome; Mechanical ventilation; Ventilator-induced lung injury; Pathophysiology
Core Tip	Lung protective ventilation has become the standard treatment strategy for patients with acute respiratory distress syndrome (ARDS). The physiological basis of prone positioning seems to act beneficially in most pathophysiological disorders of ARDS improving hemodynamics, gas exchange and respiratory mechanics. Moreover prone positioning seems to exert an additional beneficial effect against ventilator-induced lung injury. In patients with severe ARDS, early use of prolonged prone positioning in conjunction with lung-protective strategies decreases mortality significantly.
Publish Date	2016-04-25 21:07
Citation	Koulouras V, Papathanakos G, Papathanasiou A, Nakos G. Efficacy of prone position in acute respiratory distress syndrome patients: A pathophysiology-based review. World J Crit Care Med 2016; 5(2): 121-136
URL	http://www.wjgnet.com/2220-3141/full/v5/i2/121.htm
DOI	http://dx.doi.org/10.5492/wjccm.v5.i2.121

Full Article (PDF)	WJCCM-5-121.pdf
Full Article (Word)	WJCCM-5-121.doc
Manuscript File	23523-Review.docx
Answering Reviewers	23523-Answering reviewers.pdf
Audio Core Tip	23523-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	23523-Conflict-of-interest statement.pdf
Copyright License Agreement	23523-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	23523-Language certificate.pdf
Peer-review Report	23523-Peer-review(s).pdf
Scientific Misconduct Check	23523-Scientific misconduct check.pdf
Scientific Editor Work List	23523-Scientific editor work list.pdf