Publication Name	World Journal of Gastroenterology
Manuscript ID	24106
Country	Germany

Received	2016-01-07 17:05
Peer-Review Started	2016-01-08 08:05
To Make the First Decision	2016-03-07 08:33
Return for Revision	2016-03-08 16:11
Revised
Second Decision	2016-04-26 12:02
Accepted by Journal Editor-in-Chief	2016-04-28 14:47
Accepted by Company Editor-in-Chief	2016-05-04 16:42
Articles in Press	2016-05-04 16:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-05-13 10:00
Publish the Manuscript Online	2016-06-13 09:14

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Dermatology
Manuscript Type	Clinical Trials Study
Article Title	Intestinal-borne dermatoses significantly improved by oral application of Escherichia coli Nissle 1917
Manuscript Source	Invited Manuscript
All Author List	Elina Manzhalii, Daniel Hornuss and Wolfgang Stremmel
Funding Agency and Grant Number
Corresponding Author	Elina Manzhalii, MD, Department of Propedeutics of Internal Medicine 2, Bogomolets National Medical University, 02097 City of Kiev, Ukraine. wolfgang.stremmel@med.uni-heidelberg.de
Key Words	Intestinal-borne dermatoses; Escherichia coli Nissle 1917; Immunological response; IgA; Interleukin-8; Interferon-a; Gut microbiota
Core Tip	The occurrence of facial dermatoses with erythematous papular-pustular exanthemas is often linked to intestinal inflammation. However, the underlying mechanism remains unclear, and innovative treatment options are missing. Here we show that patients with these dermatoses carry a more aggressive microbiota associated with suppressed serum IgA levels, but increase of the proinflammatory cytokines interleukin-8 and interferon-a. Clinical manifestation, microbiota and inflammatory parameters are significantly improved by application of Escherichia coli Nissle. It indicates the usefulness of this probiotic therapy in a neglected patient population in desperate need for effective help.
Publish Date	2016-06-13 09:14
Citation	Manzhalii E, Hornuss D, Stremmel W. Intestinal-borne dermatoses significantly improved by oral application of Escherichia coli Nissle 1917. World J Gastroenterol 2016; 22(23): 5415-5421
URL	http://www.wjgnet.com/1007-9327/full/v22/i23/5415.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i23.5415

Full Article (PDF)	WJG-22-5415.pdf
Full Article (Word)	WJG-22-5415.doc
Manuscript File	24106-Review.docx
Answering Reviewers	24106-Answerig reviewers.pdf
Audio Core Tip	24106-Audio core tip.mp3
Biostatistics Review Certificate	24106-Biostatistics statement.pdf
Clinical Trial Registration Statement	24106-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	24106-Conflict-of-interest statement.pdf
Copyright License Agreement	24106-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	24106-Institutional review board statement.pdf
Peer-review Report	24106-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	24106-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	24106-Scientific misconduct check.pdf
Scientific Editor Work List	24106-Scientific editor work list.pdf