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7/8/2016 9:44:00 AM | Browse: 671 | Download: 862
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 24824
Country/Territory Japan
2016-02-16 09:52
Peer-Review Started
2016-02-17 15:59
To Make the First Decision
2016-03-09 10:02
Return for Revision
2016-03-10 10:45
2016-03-19 10:06
Second Decision
2016-03-31 14:37
Accepted by Journal Editor-in-Chief
2016-03-31 16:28
Accepted by Company Editor-in-Chief
2016-04-11 11:31
Articles in Press
2016-04-11 17:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-06-29 16:58
Publish the Manuscript Online
2016-07-08 09:44
ISSN 1948-5204 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Basic Study
Article Title MicroRNA-320 family is downregulated in colorectal adenoma and affects tumor proliferation by targeting CDK6
Manuscript Source Unsolicited Manuscript
All Author List Toshihiro Tadano, Yoichi Kakuta, Shin Hamada, Yosuke Shimodaira, Masatake Kuroha, Yoko Kawakami, Tomoya Kimura, Hisashi Shiga, Katsuya Endo, Atsushi Masamune, Seiichi Takahashi, Yoshitaka Kinouchi and Tooru Shimosegawa
Funding Agency and Grant Number
Corresponding Author Toshihiro Tadano, MD, Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, Sendai, 980-8574, Japan. md465719@med.tohoku.ac.jp
Key Words CDK6; Colorectal cancer; MiR-320 family; Colorectal adenoma; Laterally spreading type
Core Tip We investigated for the first time the sequential changes of miRNA expression profiles in colonic lesions from matched samples; histologically, non-neoplastic mucosa, adenoma, and submucosal invasive carcinoma were microdissected from a tissue sample. We have shown that the miR-320a, miR-320b, miR-320c, miR-320d are downregulated from colorectal adenoma and miR-320e is downregulated from colorectal submucosal carcinoma tissue and the miR-320 family suppresses tumor proliferation by targeting CDK6. The miR-320 family may play an important role in the growth of colorectal tumors and can be considered as a biomarker for the early detection of colorectal tumors.
Publish Date 2016-07-08 09:44
Citation Tadano T, Kakuta Y, Hamada S, Shimodaira Y, Kuroha M, Kawakami Y, Kimura T, Shiga H, Endo K, Masamune A, Takahashi S, Kinouchi Y, Shimosegawa T. MicroRNA-320 family is downregulated in colorectal adenoma and affects tumor proliferation by targeting CDK6. World J Gastrointest Oncol 2016; 8(7): 532-542
URL http://www.wjgnet.com/1948-5204/full/v8/i7/532.htm
DOI http://dx.doi.org/10.4251/wjgo.v8.i7.532
Full Article (PDF) WJGO-8-532.pdf
Full Article (Word) WJGO-8-532.doc
Manuscript File 24824-Review.docx
Answering Reviewers 24824-Answering reviewers.pdf
Audio Core Tip 24824-Audio core tip.wma
Biostatistics Review Certificate 24824-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 24824-Conflict-of-interest statement.pdf
Copyright License Agreement 24824-Copyright assignment.pdf
Data Sharing Statement 24824-Data sharing statement.pdf
Institutional Review Board Approval Form or Document 24824-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 24824-Language certificate.pdf
Peer-review Report 24824-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 24824-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 24824-Scientific misconduct check.pdf
Scientific Editor Work List 24824-Scientific editor work list.pdf