| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
MicroRNA-320 family is downregulated in colorectal adenoma and affects tumor proliferation by targeting CDK6
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Toshihiro Tadano, Yoichi Kakuta, Shin Hamada, Yosuke Shimodaira, Masatake Kuroha, Yoko Kawakami, Tomoya Kimura, Hisashi Shiga, Katsuya Endo, Atsushi Masamune, Seiichi Takahashi, Yoshitaka Kinouchi and Tooru Shimosegawa |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Toshihiro Tadano, MD, Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, Sendai, 980-8574, Japan. md465719@med.tohoku.ac.jp |
| Key Words |
CDK6; Colorectal cancer; MiR-320 family; Colorectal adenoma; Laterally spreading type |
| Core Tip |
We investigated for the first time the sequential changes of miRNA expression profiles in colonic lesions from matched samples; histologically, non-neoplastic mucosa, adenoma, and submucosal invasive carcinoma were microdissected from a tissue sample. We have shown that the miR-320a, miR-320b, miR-320c, miR-320d are downregulated from colorectal adenoma and miR-320e is downregulated from colorectal submucosal carcinoma tissue and the miR-320 family suppresses tumor proliferation by targeting CDK6. The miR-320 family may play an important role in the growth of colorectal tumors and can be considered as a biomarker for the early detection of colorectal tumors. |
| Publish Date |
2016-07-08 09:44 |
| Citation |
Tadano T, Kakuta Y, Hamada S, Shimodaira Y, Kuroha M, Kawakami Y, Kimura T, Shiga H, Endo K, Masamune A, Takahashi S, Kinouchi Y, Shimosegawa T. MicroRNA-320 family is downregulated in colorectal adenoma and affects tumor proliferation by targeting CDK6. World J Gastrointest Oncol 2016; 8(7): 532-542 |
| URL |
http://www.wjgnet.com/1948-5204/full/v8/i7/532.htm |
| DOI |
http://dx.doi.org/10.4251/wjgo.v8.i7.532 |
