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6/19/2016 9:16:00 PM | Browse: 285 | Download: 251
Publication Name World Journal of Psychiatry
Manuscript ID 25243
Country of Manuscript Source Lebanon
Received
2016-03-01 08:39
Peer-Review Started
2016-03-01 10:01
To Make the First Decision
2016-03-21 13:59
Return for Revision
2016-03-22 08:45
Revised
2016-04-16 04:25
Second Decision
2016-04-26 16:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-05-11 15:53
Articles in Press
2016-05-11 15:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-05-25 17:38
Publish the Manuscript Online
2016-06-19 21:16
ISSN 2220-3206 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Psychiatry
Manuscript type Minireviews
Article Title Linking multiple pathogenic pathways in Alzheimer’s disease
Manuscript Source Invited Manuscript
All Author List Rami Bou Khalil, Elie Khoury and Salam Koussa
Funding Agency and Grant Number
Correspondence To Rami Bou Khalil, MD, Department of Psychiatry, Hotel Dieu de France Hospital, Saint Joseph University, A. Naccache Boulevard Street, Achrafieh, PO Box 166830, Beirut, Lebanon. ramiboukhalil@hotmail.com
Keywords Alzheimer’s disease; Etiologies; Iron; Oxidative stress; Thrombin; Vascular risk factors
Core Tip Patients with Alzheimer’s disease (AD) have not benefited from any disease-modifying drug until now. Multiple etiologic pathways have been explored and suggest promising solutions in the future. The iron chelator deferoxamine is one potential therapeutic solution around which future studies are being directed. Another potential therapeutic solution is related to thrombin inhibitors. In this minireview, a common pathophysiological pathway is suggested for the pathogenesis of AD that is initiated by the presence of vascular risk factors inducing brain tissue hypoxia and endothelial cell activation. In predisposed individuals, this can lead to thrombin activation and iron decompartmentalization. The resulting oxidative stress will eventually lead to neuronal and glial cell death.
Publish Date 2016-06-19 21:16
Citation Bou Khalil R, Khoury E, Koussa S. Linking multiple pathogenic pathways in Alzheimer’s disease. World J Psychiatr 2016; 6(2): 208-214
Url http://www.wjgnet.com/2220-3206/full/v6/i2/208.htm
DOI http://dx.doi.org/10.5498/wjp.v6.i2.208
Full Article (PDF) WJP-6-208.pdf
Full Article (Word) WJP-6-208.doc
Manuscript File 25243-Review.docx
Answering Reviewers 25243-Answering reviewers.pdf
Audio Core Tip 25243-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 25243-Conflict-of-interest statement.pdf
Copyright License Agreement 25243-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 25243-Language certificate.pdf
Supplementary Material Supplementary_Material_20160301020141.docx
Peer-review Report 25243-Peer-review(s).pdf
Scientific Misconduct Check 25243-Scientific misconduct check.pdf
Scientific Editor Work List 25243-Scientific editor work list.pdf