Publication Name	World Journal of Virology
Manuscript ID	25652
Country	Italy

Received	2016-03-18 09:09
Peer-Review Started	2016-03-21 18:01
To Make the First Decision	2016-04-15 08:23
Return for Revision	2016-04-19 16:49
Revised	2016-05-03 20:24
Second Decision	2016-06-27 17:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-07-13 14:05
Articles in Press	2016-07-13 14:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-08-03 14:51
Publish the Manuscript Online	2016-08-11 08:15

ISSN	2220-3249 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Virology
Manuscript Type	Review
Article Title	Intrinsic host restriction factors of human cytomegalovirus replication and mechanisms of viral escape
Manuscript Source	Invited Manuscript
All Author List	Santo Landolfo, Marco De Andrea, Valentina Dell’Oste and Francesca Gugliesi
Funding Agency and Grant Number	Funding Agency Grant Number Italian Ministry of Education, University and Research 2012SNMJR V. Dell’Oste 20127MFYBR S. Landolfo PAR-FCS 2007/2013
Corresponding Author	Santo Landolfo, MD, PhD, Department of Public Health and Pediatric Sciences, Laboratory of Patho­genesis of Viral Infections, University of Turin, Via Santena 9, 10126 Turin, Italy. santo.landolfo@unito.it
Key Words	Human cytomegalovirus; Intrinsic immunity; Restriction factors; Viral escape mechanisms; DNA sensors
Core Tip	Cellular “restriction factors”, active before human cytomegalovirus (HCMV) enters the cells, form a component of the intrinsic resistance to virus infection. Examples of such factors are hDaxx, promyelocytic leukemia, Sp100 - components of ND10 - and IFN-γ inducible protein 16 (IFI16), an Interferon-inducible protein of the Pyrin/HIN domain protein family. Over time, viruses have developed mechanisms to counteract ND10 and IFI16 through viral proteins, such as IE1 and pp71, or UL97 and pp65, respectively. Detailed knowledge of these mechanisms will provide new competencies useful to control HCMV infection and, in turn, contribute to the development of novel therapeutic approaches.
Publish Date	2016-08-11 08:15
Citation	Landolfo S, De Andrea M, Dell’Oste V, Gugliesi F. Intrinsic host restriction factors of human cytomegalovirus replication and mechanisms of viral escape. World J Virol 2016; 5(3): 87-96
URL	http://www.wjgnet.com/2220-3249/full/v5/i3/87.htm
DOI	http://dx.doi.org/10.5501/wjv.v5.i3.87

Full Article (PDF)	WJV-5-87.pdf
Full Article (Word)	WJV-5-87.doc
Manuscript File	25652-Review.docx
Answering Reviewers	25652-Answering reviewers.pdf
Audio Core Tip	25652-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	25652-Conflict-of-interest statement.pdf
Copyright License Agreement	25652-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	25652-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	25652-Language certificate.pdf
Peer-review Report	25652-Peer-review(s).pdf
Scientific Misconduct Check	25652-Scientific misconduct check.pdf
Scientific Editor Work List	25652-Scientific editor work list.pdf